Clopidogrel desensitization protocol for the treatment of thienopyridine hypersensitivity

Nicholas E Walker; Mary B Fasano; Ryan A Hobbs; Phillip A Horwitz

doi:10.1097/01.hpc.0000256476.82317.77

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Clopidogrel desensitization protocol for the treatment of thienopyridine hypersensitivity

Journal article

Peer reviewed

Clopidogrel desensitization protocol for the treatment of thienopyridine hypersensitivity

Nicholas E Walker, Mary B Fasano, Ryan A Hobbs and Phillip A Horwitz

Critical pathways in cardiology, Vol.6(1), pp.26-29

03/2007

DOI: 10.1097/01.hpc.0000256476.82317.77

PMID: 17667884

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Abstract

The antiplatelet agent clopidogrel has become a mainstay of treatment of patients with acute coronary syndromes and strokes, and to reduce ischemic complications after percutaneous coronary and peripheral interventions. As the use of this agent has become more widespread, hypersensitivity reactions to clopidogrel have been increasingly recognized. This problem can be difficult to manage, especially in patients who are in need of or have recently undergone intracoronary stenting, as therapeutic alternatives are limited. Our previously published experience shows that desensitization can allow clopidogrel to be used safely in these patients. The protocol is simple, rapid, and can be conducted by a team of cardiology and allergy-immunology specialists. This article outlines the procedural details of the protocol.

Drug Hypersensitivity - etiology

Drug Hypersensitivity - prevention & control

Ticlopidine - immunology

Humans

Clinical Protocols

Ticlopidine - analogs & derivatives

Angioplasty, Balloon, Coronary

Patient Selection

Algorithms

Exanthema - chemically induced

Platelet Aggregation Inhibitors - administration & dosage

Ticlopidine - adverse effects

Ticlopidine - administration & dosage

Platelet Aggregation Inhibitors - immunology

Stents

Desensitization, Immunologic - methods

Platelet Aggregation Inhibitors - adverse effects

Details

Title: Subtitle: Clopidogrel desensitization protocol for the treatment of thienopyridine hypersensitivity
Creators: Nicholas E Walker - Department of Internal Medicine, Division of Cardiovascular Diseases, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA
Mary B Fasano
Ryan A Hobbs
Phillip A Horwitz
Resource Type: Journal article
Publication Details: Critical pathways in cardiology, Vol.6(1), pp.26-29
DOI: 10.1097/01.hpc.0000256476.82317.77
PMID: 17667884
ISSN: 1535-282X
eISSN: 1535-2811
Language: English
Date published: 03/2007
Academic Unit: Stead Family Department of Pediatrics; Cardiovascular Medicine; Rheumatology, Allergy, and Immunology; Immunology; Internal Medicine
Record Identifier: 9984093222102771

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