Journal article
Clopidogrel use as a risk factor for poor outcomes after kidney transplantation
The American journal of surgery, Vol.208(4), pp.556-562
10/01/2014
DOI: 10.1016/j.amjsurg.2014.06.007
PMID: 25241952
Abstract
BACKGROUND: Limited data are available on outcome implications of clopidogrel use before kidney transplantation.
METHODS: A novel dataset linking national transplant registry data with records from a large pharmacy claims clearinghouse (2005 to 2010) was examined to estimate risks of post-transplant death and graft failure associated with clopidogrel fills within 90 or more than 90 days before transplant.
RESULTS: Clopidogrel fills within 90 days of transplant were associated with 61% of increased relative mortality risk and 23% of increased graft failure risk. Risks were higher in those whose last clopidogrel fill was more than 90 days before transplantation (111% for death, 59% for graft loss). Adverse prognostic associations persisted among recipients of live and deceased donor allografts, older recipients, and those with diabetes or reported cardiovascular disease.
CONCLUSIONS: Clopidogrel use before kidney transplantation portends increased risks of post-transplant death and graft loss. Pharmacy claims may identify novel prognostic markers not currently captured in the transplant registry. (C) 2014 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Clopidogrel use as a risk factor for poor outcomes after kidney transplantation
- Creators
- Jennifer M. Williams - Saint Louis UniversityJanet E. Tuttle-Newhall - Saint Louis UniversityMark Schnitzler - Saint Louis UniversityNino Dzebisashvili - Dartmouth–Hitchcock Medical CenterHuiling Xiao - Saint Louis UniversityDavid Axelrod - Dartmouth–Hitchcock Medical CenterHarveshp Mogal - Saint Louis UniversityKrista L. Lentine - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.208(4), pp.556-562
- Publisher
- Elsevier
- DOI
- 10.1016/j.amjsurg.2014.06.007
- PMID
- 25241952
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Number of pages
- 7
- Language
- English
- Date published
- 10/01/2014
- Academic Unit
- Surgery
- Record Identifier
- 9984322811802771
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