Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH): Report From the AOSSM/NIH U-13 Post–Joint Injury Osteoarthritis Conference II

Constance R Chu; Bruce D Beynnon; Joseph A Buckwalter; William E Garrett; Jeffrey N Katz; Scott A Rodeo; Kurt P Spindler; Robert A Stanton

doi:10.1177/0363546511411654

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Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH): Report From the AOSSM/NIH U-13 Post–Joint Injury Osteoarthritis Conference II

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Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH): Report From the AOSSM/NIH U-13 Post–Joint Injury Osteoarthritis Conference II

Constance R Chu, Bruce D Beynnon, Joseph A Buckwalter, William E Garrett, Jeffrey N Katz, Scott A Rodeo, Kurt P Spindler and Robert A Stanton

The American journal of sports medicine, Vol.39(7), pp.1569-1578

07/2011

DOI: 10.1177/0363546511411654

PMCID: PMC3182453

PMID: 21730208

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https://www.ncbi.nlm.nih.gov/pmc/articles/3182453View

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Abstract

This report summarizes the 2010 AOSSM/NIH (American Orthopaedic Society for Sports Medicine/National Institutes of Health) U13 Post–Joint Injury Osteoarthritis II Conference to include the discussion concerning potential study cohorts, assessment considerations, and research priorities. There was strong consensus and enthusiasm for approaching the development of disease-modifying treatments for osteoarthritis through study of “pre-osteoarthritic” cohorts, particularly human subjects under 30 years of age following acute anterior cruciate ligament injuries. Clinical study of acute treatment strategies initiated within a few days after injury will need development of recruitment pathways and short-term proof-of-concept outcome measures that are specific to the intervention being studied. For example, measures of joint inflammation can be used in short-term prospective randomized controlled trials to determine whether an anti-inflammatory intervention was effective in decreasing early inflammation. These short-term clinical trials will need to be followed by longer-term evaluation of the clinical cohorts for joint and cartilage degeneration to determine if the acute intervention affected later development of osteoarthritis. Research priorities were identified in several disciplines, particularly regarding development and validation of quantitative imaging, biomechanics, and biomarker measures of joint structure, composition, and function that predict the accelerated development of osteoarthritis. Systematic study of posttraumatic osteoarthritis is anticipated to advance understanding and treatment of all forms of osteoarthritis.

clinical trials

anterior cruciate ligament tear

osteoarthritis

joint injury

Details

Title: Subtitle: Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH): Report From the AOSSM/NIH U-13 Post–Joint Injury Osteoarthritis Conference II
Creators: Constance R Chu - University of Pittsburgh, Department of Orthopaedic Surgery, Cartilage Restoration Center, Pittsburgh, Pennsylvania
Bruce D Beynnon - University of Vermont College of Medicine, Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, Burlington, Vermont
Joseph A Buckwalter - The University of Iowa, Department of Orthopaedic Surgery, Iowa City, Iowa
William E Garrett - Duke University, Department of Orthopaedics, Durham, North Carolina
Jeffrey N Katz - Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts
Scott A Rodeo - Hospital for Special Surgery, Department of Orthopaedic Surgery, New York, New York
Kurt P Spindler - Vanderbilt University, Department of Orthopaedic Surgery, Nashville, Tennessee
Robert A Stanton - Orthopaedic Specialty Group, Fairfield, Connecticut
Resource Type: Journal article
Publication Details: The American journal of sports medicine, Vol.39(7), pp.1569-1578
DOI: 10.1177/0363546511411654
PMID: 21730208
PMCID: PMC3182453
NLM abbreviation: Am J Sports Med
ISSN: 0363-5465
eISSN: 1552-3365
Grant note: R01 AR052784-06A1 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-03S1 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-07 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-04 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-01A1 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-03 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-05 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR052784-02 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS U13 AR060692-01 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
Language: English
Date published: 07/2011
Academic Unit: Stead Family Department of Pediatrics; Orthopedics and Rehabilitation; Injury Prevention Research Center
Record Identifier: 9984040329802771

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