Clostridium Difficile –Associated Diarrhea in a Tertiary Care Medical Center

Marilee Obritsch; Jeffrey Stroup; Ryan Carnahan; David Scheck

doi:10.1080/08998280.2010.11928654

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Clostridium Difficile –Associated Diarrhea in a Tertiary Care Medical Center

Journal article

Open access

Peer reviewed

Clostridium Difficile –Associated Diarrhea in a Tertiary Care Medical Center

Marilee Obritsch, Jeffrey Stroup, Ryan Carnahan and David Scheck

Baylor University Medical Center Proceedings, Vol.23(4), pp.363-367

2010

DOI: 10.1080/08998280.2010.11928654

PMID: 20944758

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Abstract

This retrospective, case-control study aimed to identify variables associated with the incidence of Clostridium difficile-associated diarrhea (CDAD) in acute care facilities and to specifically identify the relationship of fluoroquinolones and acid suppressive agents in the development of CDAD. Seventy-one symptomatic patients positive for C. difficile toxin A or B hospitalized for at least 72 hours were compared with 142 control patients hospitalized for at least 72 hours who were not positive for C. difficile toxin A or B. Two controls were matched to one case patient for age within 5 years, unit of admission, and date of admission. The mean ages for cases and controls were 63.5 and 62.7 years, respectively. After adjusting for two confounding variables-hospital stay within 3 months and Charlson Comorbidity Index-conditional multiple logistic regression identified six risk factors for development of CDAD: gastrointestinal procedures within 60 days (odds ratio [OR] 9.1, P < 0.013), levofloxacin exposure (OR 8.2, P < 0.033), moxifloxacin exposure (OR 4.1, P < 0.026), imipenem exposure (OR 14.9, P < 0.014), laxative use (OR 20.2, P < 0.0001), and immunosuppressive use (OR 20.7, P < 0.034). The risk of CDAD after exposure to levofloxacin or moxifloxacin was not significantly different. Acid suppressive therapy was not a risk factor for CDAD development.

Details

Title: Subtitle: Clostridium Difficile –Associated Diarrhea in a Tertiary Care Medical Center
Creators: Marilee Obritsch
Jeffrey Stroup
Ryan Carnahan
David Scheck
Resource Type: Journal article
Publication Details: Baylor University Medical Center Proceedings, Vol.23(4), pp.363-367
DOI: 10.1080/08998280.2010.11928654
PMID: 20944758
NLM abbreviation: Proc (Bayl Univ Med Cent)
ISSN: 1525-3252
eISSN: 1525-3252
Language: English
Date published: 2010
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9983995159402771

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