Journal article
Clostridium difficile–associated diarrhea: an emerging threat to pregnant women
American journal of obstetrics and gynecology, Vol.198(6), pp.635.e1-635.e6
2008
DOI: 10.1016/j.ajog.2008.01.062
PMID: 18395693
Abstract
To estimate if Clostridium difficile-associated disease (CDAD) is increasing in peripartum women.
Peripartum CDAD was assessed through 1) passive surveillance collecting clinical and pathology data on severe cases and 2) survey among infectious disease consultants (ICDs) in the Emerging Infections Network.
Ten severe cases were collected; most had associated antibiotic use. Seven women were either admitted to the ICU or underwent colectomy. Three infants were stillborn, and 3 women died. The epidemic
Clostridium difficile strain was found in 2 cases. Among 798 ICDs, 419 (52%) participated in the survey. Thirty-seven respondents (9%) recalled 55 cases, mostly in the postpartum period with 21 complications, mainly due to relapse.
Severe CDAD may be increasing in peripartum women. Clinicians should have a low threshold for testing, be aware of the potential for severe outcomes, and take steps to reduce both the risk of disease and resultant complications.
Details
- Title: Subtitle
- Clostridium difficile–associated diarrhea: an emerging threat to pregnant women
- Creators
- Nadine G Rouphael - Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GAJudith A O'Donnell - Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PAJulu Bhatnagar - Infectious Diseases Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GAFelicia Lewis - Epidemic Intelligence Service Field Assignments Branch, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GAPhilip M Polgreen - Infectious Diseases Society of America Emerging Infections Network, Iowa City, IASusan Beekmann - Infectious Diseases Society of America Emerging Infections Network, Iowa City, IAJeannette Guarner - Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GAGeorge E Killgore - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GABecky Coffman - Oklahoma State Department of Health, Oklahoma City, OKJennifer Campbell - Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PASherif R Zaki - Infectious Diseases Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GAL. Clifford McDonald - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.198(6), pp.635.e1-635.e6
- DOI
- 10.1016/j.ajog.2008.01.062
- PMID
- 18395693
- NLM abbreviation
- Am J Obstet Gynecol
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Infectious Diseases; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984094374502771
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