Clozapine Prolongs Cortical Silent Period in Patients with Treatment-Resistant Schizophrenia

Atsuhiro Miyazawa; Nobuhisa Kanahara; Yusuke Nakata; Satoshi Kodama; Hiroshi Kimura; Atsushi Kimura; Yasunori Oda; Hiroyuki Watanabe; Masaomi Iyo

doi:10.64719/pb.4403

Journal article

Clozapine Prolongs Cortical Silent Period in Patients with Treatment-Resistant Schizophrenia

Atsuhiro Miyazawa, Nobuhisa Kanahara, Yusuke Nakata, Satoshi Kodama, Hiroshi Kimura, Atsushi Kimura, Yasunori Oda, Hiroyuki Watanabe and Masaomi Iyo

Psychopharmacology bulletin, Vol.51(2), pp.20-30

03/16/2021

DOI: 10.64719/pb.4403

PMID: 34092820

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Abstract

Although clozapine exhibited high efficacy for treating the symptoms of patients with treatment-resistant schizophrenia (TRS), its precise action mechanisms have not been fully understood. Recently, accumulating evidence has suggested the presence of abnormalities in the gamma-aminobutyric acid (GABA) systems in patients with schizophrenia, and the potential effects of clozapine on GABA receptors have gained a great deal of attention. In the present study, the cortical silent period (CSP), an electrophysiological parameter of GABA function via GABA receptors, was measured using with the transcranial magnetic stimulation in patients with schizophrenia and healthy control subjects. Then the CSP of patients treated with clozapine (N = 12) was compared with that of patients treated with other antipsychotics (N = 25) and with that of healthy controls (N = 27). The CSP of the patients treated with clozapine was significantly longer compared to those of the other two groups. The CSP of patients treated with other antipsychotics was similar to that of healthy subjects. There was a positive correlation between CSP and global assessment of function (GAF) in patients with TRS. The present study indicated that CSP was prolonged in patients receiving clozapine, and suggested that clozapine enhances the transmission signal via GABAB receptors.

GABA

antipsychotic

transcranial magnetic stimulation

treatment-resistant

cortical inhibition

Details

Title: Subtitle: Clozapine Prolongs Cortical Silent Period in Patients with Treatment-Resistant Schizophrenia
Creators: Atsuhiro Miyazawa - Chiba University
Nobuhisa Kanahara - Chiba University
Yusuke Nakata - Chiba University
Satoshi Kodama - Chiba University
Hiroshi Kimura - Chiba University
Atsushi Kimura - Chiba University
Yasunori Oda - Chiba University
Hiroyuki Watanabe - Chiba University
Masaomi Iyo - Chiba University
Resource Type: Journal article
Publication Details: Psychopharmacology bulletin, Vol.51(2), pp.20-30
DOI: 10.64719/pb.4403
PMID: 34092820
NLM abbreviation: Psychopharmacol Bull
ISSN: 2472-2448
eISSN: 2472-2448
Language: English
Date published: 03/16/2021
Academic Unit: Neurology
Record Identifier: 9985177942402771

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