Journal article
Co-Crystals of Caffeine and Hydroxy-2-naphthoic Acids: Unusual Formation of the Carboxylic Acid Dimer in the Presence of a Heterosynthon
Molecular pharmaceutics, Vol.4(3), pp.339-346
06/01/2007
DOI: 10.1021/mp070004b
PMID: 17489605
Abstract
A group of caffeine-containing co-crystals of hydroxy-2-naphthoic acids were synthesized and analyzed via single-crystal X-ray diffraction and IR analysis. The imidazole-carboxylic acid synthon was observed in co-crystals involving 1-hydroxy-2-naphthoic and 3-hydroxy-2-naphthoic acid. In the case of 6-hydroxy-2-naphthoic acid, the co-crystal exhibits a hydrogen-bonded carboxylic acid dimer in the presence of a hydroxyl-caffeine heterosynthon. © 2007 American Chemical Society.
Details
- Title: Subtitle
- Co-Crystals of Caffeine and Hydroxy-2-naphthoic Acids: Unusual Formation of the Carboxylic Acid Dimer in the Presence of a Heterosynthon
- Creators
- Dejan-Krešimir Bučar - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Rodger F Henry - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Xiaochun Lou - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Richard W Duerst - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Thomas B Borchardt - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Leonard R MacGillivray - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064Geoff G. Z Zhang - Solid State Sciences, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, Microscopy Group, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, Illinois 60064, and Solid State Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, North Chicago, Illinois 60064
- Resource Type
- Journal article
- Publication Details
- Molecular pharmaceutics, Vol.4(3), pp.339-346
- DOI
- 10.1021/mp070004b
- PMID
- 17489605
- ISSN
- 1543-8384
- eISSN
- 1543-8392
- Language
- English
- Date published
- 06/01/2007
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216671902771
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