Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study

Frank W Roemer; David T Felson; Ke Wang; Michel D Crema; Tuhina Neogi; Yuqing Zhang; Michael C Nevitt; Monica D Marra; Cora E Lewis; James Torner; Ali Guermazi; MOST study investigators

doi:10.1136/annrheumdis-2012-201810

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Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study

Journal article

Peer reviewed

Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study

Frank W Roemer, David T Felson, Ke Wang, Michel D Crema, Tuhina Neogi, Yuqing Zhang, Michael C Nevitt, Monica D Marra, Cora E Lewis, James Torner, …

Annals of the rheumatic diseases, Vol.72(6), pp.942-948

06/2013

DOI: 10.1136/annrheumdis-2012-201810

PMCID: PMC3871211

PMID: 22956600

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https://www.ncbi.nlm.nih.gov/pmc/articles/3871211View

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Abstract

To assess risk of cartilage loss in the tibiofemoral joint in relation to baseline damage severity, and to analyse the association of nearby pathologic findings on the risk of subsequent cartilage loss. The Multicenter Osteoarthritis Study is a longitudinal study of individuals with or at high risk for knee osteoarthritis. MRI examinations were assessed according to the Whole Organ MRI Score. Included were all knees with available baseline and 30 months MRIs. Ordinal logistic regression was used to estimate risk of cartilage loss in each subregion in relation to the number of associated articular features including bone marrow lesions, meniscal damage and extrusion and also in regard to baseline damage severity, respectively. 13 524 subregions of 1365 knees were included. 3777 (27.9%) subregions exhibited prevalent cartilage damage at baseline and 1119 (8.3%) subregions showed cartilage loss at 30-month follow-up. Risk of cartilage loss was increased for subregions with associated features (OR 2.53, 95% CI 2.03 to 3.15 for one, 4.32 95% CI 3.42 to 5.47 for two and 5.30 95% CI 3.95 to 7.12 for three associated features; p for trend<0.0001). Subregions with prevalent cartilage damage showed increased risk for further cartilage loss compared to subregions with intact cartilage at baseline with small superficial defects exhibiting highest risk. Risk of cartilage loss is increased for subregions with associated pathology and further increased when more than one type of associated feature is present. In addition, prevalent cartilage damage increases risk for subsequent cartilage loss.

Magnetic Resonance Imaging

Bone Marrow Diseases - complications

Prospective Studies

Humans

Middle Aged

Logistic Models

Male

Bone Marrow Diseases - pathology

Disease Progression

Cartilage, Articular - pathology

Menisci, Tibial - pathology

Osteoarthritis, Knee - complications

Osteoarthritis, Knee - pathology

Aged, 80 and over

Female

Aged

Odds Ratio

Longitudinal Studies

Details

Title: Subtitle: Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study
Creators: Frank W Roemer - Department of Radiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. froemer@bu.edu
David T Felson
Ke Wang - Boston University
Michel D Crema
Tuhina Neogi
Yuqing Zhang
Michael C Nevitt
Monica D Marra
Cora E Lewis
James Torner
Ali Guermazi
MOST study investigators
Resource Type: Journal article
Publication Details: Annals of the rheumatic diseases, Vol.72(6), pp.942-948
DOI: 10.1136/annrheumdis-2012-201810
PMID: 22956600
PMCID: PMC3871211
NLM abbreviation: Ann Rheum Dis
ISSN: 0003-4967
eISSN: 1468-2060
Publisher: England
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K23 AR055127 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01-AG-18820 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01-AG-18832 / NIA NIH HHS U01-AG-18947 / NIA NIH HHS U01-AG-19069 / NIA NIH HHS U01 AR050900 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 06/2013
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983996090402771

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