Journal article
Co-registration of acquired MR ventilation and perfusion images-Validation in a porcine model
Magnetic resonance in medicine, Vol.49(1), pp.13-18
01/2003
DOI: 10.1002/mrm.10359
PMID: 12509815
Abstract
Under controlled imaging conditions, functional, co-registered ventilation and perfusion images were obtained for quantitative MRI assessment of pulmonary function. Experiments were conducted on 25-35 kg Yorkshire pigs (N = 5) under ketamine/isoflurane anesthesia. Ventilation and perfusion MR images were obtained using laser polarized gas and gadolinium (Gd), respectively. The mutual information-based technique was used to quantify the initial misregistration between the acquired ventilation and perfusion images, to cope with different intensity characteristics. Means and standard deviations (SDs) of misregistrations for the five subjects, in terms of absolute translation and absolute rotations around each of the three coordinate axes, were computed to evaluate the hypothesis. For qualitative illustrations, plots of mutual information values under absolute translations and rotations around each of the three coordinate axes are presented. This preliminary study shows the feasibility of acquiring functional image data that are spatially co-registered. This method has potential applications in the quantitative assessment of regional alveolar ventilation and pulmonary perfusion ratio, in both normal and diseased lung.
Details
- Title: Subtitle
- Co-registration of acquired MR ventilation and perfusion images-Validation in a porcine model
- Creators
- Rahim R Rizi - University of PennsylvaniaPunam K Saha - University of PennsylvaniaBinquan Wang - University of PennsylvaniaMargaret A Ferrante - University of California, Los AngelesDavid Lipson - University of PennsylvaniaJames Baumgardner - University of PennsylvaniaDavid A Roberts - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.49(1), pp.13-18
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/mrm.10359
- PMID
- 12509815
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 6
- Language
- English
- Date published
- 01/2003
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984197243702771
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