Journal article
Coaggregation to prevent dental caries
Expert opinion on therapeutic patents, Vol.16(11), pp.1601-1604
11/2006
DOI: 10.1517/13543776.16.11.1601
Abstract
This application claims that selected species of Lactobacillus, capable of co- aggregating with the cariogen Streptococcus mutans, can be administered therapeutically to prevent colonisation with S. mutans or to significantly diminish the presence of S. mutans within dental plaque. This strategy has the potential for success as S. mutans do not need to be totally eliminated to significantly diminish the probability of caries development. Mechanistically, it is predicted that the Lactobacillus will bind to S. mutans and interfere with adhesins on the S. mutans cell surface that are specific for receptors on the tooth pellicle. Aggregates of the two species will be eliminated from the oral cavity by swallowing. The most effective delivery of this technology may be during the critical 'window of infectivity in young children where preventing S. mutans colonisation promotes the establishment of a healthy, non-cariogenic plaque biofilm. The utility of this technology as a therapeutic for individuals with ongoing caries is less certain. Although either appliance is theoretically feasible, the application does not venture much beyond demonstrating in vitro coaggregation of the two species. Consequently, there are still several issues that must be experimentally addressed before the effectiveness of the technology can be established.
Details
- Title: Subtitle
- Coaggregation to prevent dental caries
- Creators
- Jeffrey A Banas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Expert opinion on therapeutic patents, Vol.16(11), pp.1601-1604
- Publisher
- Informa UK Ltd
- DOI
- 10.1517/13543776.16.11.1601
- ISSN
- 1354-3776
- eISSN
- 1744-7674
- Language
- English
- Date published
- 11/2006
- Academic Unit
- Pediatric Dentistry; Dental Research
- Record Identifier
- 9984367729002771
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