Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?

Lorraine B Ware; Julie A Bastarache; Ling Wang

doi:10.2302/kjm.54.142

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Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?

Journal article

Open access

Peer reviewed

Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?

Lorraine B Ware, Julie A Bastarache and Ling Wang

Keio journal of medicine, Vol.54(3), pp.142-149

09/2005

DOI: 10.2302/kjm.54.142

PMID: 16237276

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Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common, life-threatening causes of acute respiratory failure that arise from a variety of local and systemic insults. The need for new specific therapies has led a number of investigators to examine the role of altered coagulation and fibrinolysis in the pathogenesis of ALI/ARDS. This review summarizes our current understanding of coagulation and fibrinolysis in human ALI/ARDS with an emphasis on pathways that could be potential therapeutic targets including the tissue factor pathway, the protein C pathway and modulation of fibrinolysis via plasminogen activator inhibitor-1. The available data suggest that clinical ALI and ARDS are characterized by profound alterations in both systemic and intra-alveolar coagulation and fibrinolysis. Fibrin deposition in the airspaces and lung microvasculature likely results from both activation of the coagulation cascade and impaired fibrinolysis, triggered by inflammation. Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration.

Blood Coagulation

Fibrinolysis

Humans

Lipoproteins - metabolism

Plasminogen Activator Inhibitor 1 - metabolism

Plasminogen Activators - metabolism

Protein C - metabolism

Respiratory Distress Syndrome, Adult - blood

Respiratory Distress Syndrome, Adult - therapy

Thrombomodulin - metabolism

Thromboplastin - metabolism

Details

Title: Subtitle: Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?
Creators: Lorraine B Ware - Vanderbilt University
Julie A Bastarache - Vanderbilt University
Ling Wang - Vanderbilt University
Resource Type: Journal article
Publication Details: Keio journal of medicine, Vol.54(3), pp.142-149
DOI: 10.2302/kjm.54.142
PMID: 16237276
NLM abbreviation: Keio J Med
ISSN: 0022-9717
eISSN: 1880-1293
Language: English
Date published: 09/2005
Academic Unit: Orthopedics and Rehabilitation
Record Identifier: 9984304714702771

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