Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment

Ganary Dabiri; Elizabeth Damstetter; Yunyoung Chang; Emily Baiyee Ebot; Jennifer Gloeckner Powers; Tania Phillips

doi:10.1016/j.jaad.2015.08.071

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Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment

Journal article

Peer reviewed

Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment

Ganary Dabiri, Elizabeth Damstetter, Yunyoung Chang, Emily Baiyee Ebot, Jennifer Gloeckner Powers and Tania Phillips

Journal of the American Academy of Dermatology, Vol.74(5), pp.795-804

05/2016

DOI: 10.1016/j.jaad.2015.08.071

PMID: 27085226

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Abstract

Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. Inherited conditions tend to present either in neonatal period or later in life, while acquired conditions typically occur later in life. Diagnostic studies are performed to identify the coagulation cascade deficiency or defect. Treatment primarily hinges on anticoagulation and wound care. In this article, we provide an in-depth analysis of the clinical manifestations, diagnostic considerations, and management options of patients in hypercoagulable states.

Thrombosis

hyperhomocysteinemia

thrombophilia

livedoid vasculopathy

protein C deficiency

protein S deficiency

hypercoagulable state

warfarin necrosis

factor V Leiden mutation

ulcers

Details

Title: Subtitle: Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment
Creators: Ganary Dabiri - Department of Dermatology and Skin Surgery, Roger Williams Medical Center/Boston University School of Medicine, Providence, Rhode Island
Elizabeth Damstetter - Boston University School of Medicine, Boston, Massachusetts
Yunyoung Chang - Boston University School of Medicine, Boston, Massachusetts
Emily Baiyee Ebot - Department of Hematology and Oncology, University Medical Group, Providence, Rhode Island
Jennifer Gloeckner Powers - Vanderbilt University Medical Center, Nashville, Tennessee
Tania Phillips - Boston University School of Medicine, Boston, Massachusetts
Resource Type: Journal article
Publication Details: Journal of the American Academy of Dermatology, Vol.74(5), pp.795-804
DOI: 10.1016/j.jaad.2015.08.071
PMID: 27085226
NLM abbreviation: J Am Acad Dermatol
ISSN: 0190-9622
eISSN: 1097-6787
Publisher: Elsevier Inc
Language: English
Date published: 05/2016
Academic Unit: Dermatology
Record Identifier: 9984025350102771

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