Coagulation disorders and their cutaneous presentations: Pathophysiology

Yunyoung Chang; Ganary Dabiri; Elizabeth Damstetter; Emily Baiyee Ebot; Jennifer Gloeckner Powers; Tania Phillips

doi:10.1016/j.jaad.2015.08.072

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Coagulation disorders and their cutaneous presentations: Pathophysiology

Journal article

Peer reviewed

Coagulation disorders and their cutaneous presentations: Pathophysiology

Yunyoung Chang, Ganary Dabiri, Elizabeth Damstetter, Emily Baiyee Ebot, Jennifer Gloeckner Powers and Tania Phillips

Journal of the American Academy of Dermatology, Vol.74(5), pp.783-792

05/2016

DOI: 10.1016/j.jaad.2015.08.072

PMID: 27085225

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Abstract

Hypercoagulable states are inherited or acquired predispositions to venous or arterial thromboses that are best understood in the context of the coagulation cascade. Dermatologists can play a critical role in diagnosing and treating patients with hypercoagulable states because cutaneous symptoms may be a presenting manifestation, thereby reducing morbidity and mortality related to these conditions. This review focuses on the epidemiology and pathophysiology of hypercoagulable states, while the accompanying article iterates the basic clinical features, diagnostic testing, and management of patients who have these conditions.

antiphospholipid syndrome

factor V Leiden

hyperhomocysteinemia

coagulation cascade

antithrombin

hypercoagulable state

protein C

protein S

prothrombin

cryoglobulinemia

sickle cell disease

Details

Title: Subtitle: Coagulation disorders and their cutaneous presentations: Pathophysiology
Creators: Yunyoung Chang - Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts
Ganary Dabiri - Department of Dermatology and Skin Surgery, Roger Williams Medical Center/Boston University School of Medicine, Providence, Rhode Island
Elizabeth Damstetter - Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts
Emily Baiyee Ebot - Department of Hematology and Oncology, University Medical Group, Providence, Rhode Island
Jennifer Gloeckner Powers - Vanderbilt University Medical Center, Nashville, Tennessee
Tania Phillips - Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts
Resource Type: Journal article
Publication Details: Journal of the American Academy of Dermatology, Vol.74(5), pp.783-792
DOI: 10.1016/j.jaad.2015.08.072
PMID: 27085225
NLM abbreviation: J Am Acad Dermatol
ISSN: 0190-9622
eISSN: 1097-6787
Publisher: Elsevier Inc
Language: English
Date published: 05/2016
Academic Unit: Dermatology
Record Identifier: 9984025458202771

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