Cocaine addiction in mothers: potential effects on maternal care and infant development

Lane Strathearn; Linda C Mayes

doi:10.1111/j.1749-6632.2009.05142.x

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Cocaine addiction in mothers: potential effects on maternal care and infant development

Journal article

Open access

Peer reviewed

Cocaine addiction in mothers: potential effects on maternal care and infant development

Lane Strathearn and Linda C Mayes

Annals of the New York Academy of Sciences, Vol.1187(1), pp.172-183

02/2010

DOI: 10.1111/j.1749-6632.2009.05142.x

PMCID: PMC3016156

PMID: 20201853

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https://www.ncbi.nlm.nih.gov/pmc/articles/3016156View

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Abstract

Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement. This review examines both preclinical and clinical evidence for how cocaine abuse may affect maternal care and infant development, exploring brain, behavioral, and neuroendocrine mechanisms. There is evidence that cocaine affects infant development both directly, via in utero exposure, and indirectly via alterations in maternal care. Two neural systems known to play an important role in both maternal care and cocaine addiction are the oxytocin and dopamine systems, mediating social and reward-related behaviors and stress reactivity. These same neural mechanisms may also be involved in the infant's development of vulnerability to addiction. Understanding the neuroendocrine pathways involved in maternal behavior and addiction may help facilitate earlier, more effective interventions to help substance-abusing mothers provide adequate care for their infant and perhaps prevent the intergenerational transmission of risk.

Pregnancy

Child Development

Object Attachment

Prenatal Exposure Delayed Effects - psychology

Cocaine-Related Disorders - psychology

Humans

Oxytocin - physiology

Infant

Cocaine-Related Disorders - physiopathology

Pregnancy Complications - physiopathology

Mother-Child Relations

Pregnancy Complications - psychology

Cocaine-Related Disorders - complications

Animals

Dopamine - physiology

Maternal Behavior

Female

Infant, Newborn

Neurosecretory Systems - physiopathology

Details

Title: Subtitle: Cocaine addiction in mothers: potential effects on maternal care and infant development
Creators: Lane Strathearn - The Meyer Center for Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas 77030-2399, USA. lanes@bcm.edu
Linda C Mayes
Resource Type: Journal article
Publication Details: Annals of the New York Academy of Sciences, Vol.1187(1), pp.172-183
DOI: 10.1111/j.1749-6632.2009.05142.x
PMID: 20201853
PMCID: PMC3016156
NLM abbreviation: Ann N Y Acad Sci
ISSN: 0077-8923
eISSN: 1749-6632
Publisher: Wiley; United States
Grant note: MO1RR00188 / NCRR NIH HHS K23 HD043097 / NICHD NIH HHS M01 RR000188 / NCRR NIH HHS K23 HD043097-05 / NICHD NIH HHS R01 DA-06025 / NIDA NIH HHS DA022446-01A2 / NIDA NIH HHS K23 HD43097 / NICHD NIH HHS R01 DA006025 / NIDA NIH HHS K05 DA020091 / NIDA NIH HHS
Language: English
Date published: 02/2010
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology
Record Identifier: 9984040011702771

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