Journal article
Cognition among individuals along a spectrum of increased risk for Parkinson's disease
PloS one, Vol.13(8), pp.e0201964-e0201964
2018
DOI: 10.1371/journal.pone.0201964
PMCID: PMC6101368
PMID: 30125297
Abstract
Several characteristics associated with increased risk for Parkinson's disease (PD) have been identified, including specific genotypes and various non-motor symptoms. Characterizing non-motor features, such as cognitive abilities, among individuals considered at-risk for PD is essential to improving prediction of future neurodegeneration.
Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations)). Inclusion criteria enriched the RBD and hyposmia cohorts, but not the NMC cohort, with individuals with dopamine transporter binding deficit. Baseline neuropsychological performance was compared, and analyses were adjusted for age, sex, education, and depression.
The RBD cohort performed significantly worse than the hyposmia and NMC cohorts on Symbol Digit Modality Test (mean (SD) 32.4 (9.16) vs. 41.8 (9.98), p = 0.002 and vs. 45.2 (10.9), p<0.001) and Judgment of Line Orientation (11.3 (2.36) vs.12.9 (1.87), p = 0.004 and vs. 12.9 (1.87), p<0.001). The RBD cohort also performed worse than the hyposmia cohort on the Montreal Cognitive Assessment (25.5 (4.13) vs. 27.3 (1.71), p = 0.02). Hyposmics did not differ from PD or NMC cohorts on any cognitive test score.
Among individuals across a spectrum of risk for PD, cognitive function is worse among those with the characteristic most strongly associated with future risk of PD or dementia with Lewy bodies, namely RBD.
Details
- Title: Subtitle
- Cognition among individuals along a spectrum of increased risk for Parkinson's disease
- Creators
- Lana M Chahine - University of Pittsburgh, Pittsburgh, PA, United States of AmericaLiz Urbe - The University of Iowa, Iowa City, Iowa, United States of AmericaChelsea Caspell-Garcia - The University of Iowa, Iowa City, Iowa, United States of AmericaDag Aarsland - Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, EnglandRoy Alcalay - Columbia University Medical Center, Department of Neurology, New York, NY, United States of AmericaPaolo Barone - Department of Medicine and Surgery, Center for Neurodegenerative Diseases, University of Salerno, Fisciano, ItalyDavid Burn - Institute for Ageing and Health, Newcastle University, Newcastle, United KingdomAlberto J Espay - Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH, United States of AmericaJamie L Hamilton - The Michael J. Fox Foundation for Parkinson's Research, New York, NY, United States of AmericaKeith A Hawkins - Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States of AmericaShirley Lasch - Institute for Neurodegenerative Disorders, New Haven, CT, United States of AmericaJames B Leverenz - Cleveland Clinic, Cleveland, OH, United States of AmericaIrene Litvan - UCSD Movement Disorder Center, Department of Neurosciences, University of California San Diego, San Diego, CA, United States of AmericaIrene Richard - Departments of Neurology and Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of AmericaAndrew Siderowf - Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States of AmericaChristopher S Coffey - The University of Iowa, Iowa City, Iowa, United States of AmericaTanya Simuni - Northwestern University Feinberg School of Medicine, Chicago, IL, United States of AmericaDaniel Weintraub - Parkinson's Disease and Mental Illness Research, Education and Clinical Centers (PADRECC and MIRECC), Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, United States of AmericaParkinson’s Progression Markers Initiative
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.13(8), pp.e0201964-e0201964
- DOI
- 10.1371/journal.pone.0201964
- PMID
- 30125297
- PMCID
- PMC6101368
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Language
- English
- Date published
- 2018
- Academic Unit
- Biostatistics
- Record Identifier
- 9984214800102771
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