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Cognitive-Behavioral Stress Management Decreases Dysphoric Mood and Herpes Simplex Virus-Type 2 Antibody Titers in Symptomatic HIV-Seropositive Gay Men
Journal article   Peer reviewed

Cognitive-Behavioral Stress Management Decreases Dysphoric Mood and Herpes Simplex Virus-Type 2 Antibody Titers in Symptomatic HIV-Seropositive Gay Men

Susan K Lutgendorf, Kathleen Starr, Philip McCabe, Michael H Antoni, Gail Ironson, Nancy Klimas, Mary Ann Fletcher, Mahendra Kumar, Neil Schneiderman and Karen Cleven
Journal of consulting and clinical psychology, Vol.65(1), pp.31-43
02/1997
DOI: 10.1037/0022-006X.65.1.31
PMID: 9103732

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Abstract

This study tested the effects of a 10-week group cognitive-behavioral stress management (CBSM) intervention on mood and immunologic parameters in HIV-seropositive gay men whose disease had progressed to a symptomatic stage. Men were randomized to either CBSM or a modified waiting-list control group. The CBSM intervention significantly decreased self-reported dysphoria, anxiety, and total distress. Individuals who practiced relaxation more consistently had significantly greater drops in dysphoria. The intervention also decreased herpes simplex virus-Type 2 (HSV-2) immunoglobulin G antibody titers. The control group showed no significant changes in either mood or antibody titers. Individual difference analyses revealed that decreases in dysphoria significantly predicted lower HSV-2 antibody titers by the end of the 10-week period. Neither group displayed changes in HSV-Type 1 antibody titers or in CD4+ or CD8+ cell numbers.

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