Journal article
Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics
Biological psychiatry (1969), Vol.71(4), pp.366-372
2012
DOI: 10.1016/j.biopsych.2011.10.007
PMCID: PMC3264698
PMID: 22088795
Abstract
Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-behavioral stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat.
One hundred ninety-nine women undergoing primary treatment of stage 0–III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups.
Baseline negative affect was associated with >50% differential expression of 201 leukocyte transcripts, including upregulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by >50% at follow-up (group × time interaction), including downregulation of pro-inflammatory and metastasis-related genes and upregulation of type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-κB/Rel and GATA family transcription factors and increased activity of interferon response factors and the glucocorticoid receptor as potential mediators of CBSM-induced transcriptional alterations.
In early-stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related upregulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.
Details
- Title: Subtitle
- Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics
- Creators
- Michael H Antoni - Department of Psychology, University of Miami, Coral Gables, FloridaSusan K Lutgendorf - Department of Psychology, University of Iowa, Iowa City, IowaBonnie Blomberg - Department of Microbiology and Immunology, University of Miami, Coral Gables, FloridaCharles S Carver - Department of Psychology, University of Miami, Coral Gables, FloridaSuzanne Lechner - Department of Psychiatry and Behavioral Sciences, University of Miami, Coral Gables, FloridaAlain Diaz - Department of Microbiology and Immunology, University of Miami, Coral Gables, FloridaJamie Stagl - Department of Psychology, University of Miami, Coral Gables, FloridaJesusa M.G Arevalo - School of Medicine, University of California, Los Angeles, Los Angeles, CaliforniaSteven W Cole - School of Medicine, University of California, Los Angeles, Los Angeles, California
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.71(4), pp.366-372
- DOI
- 10.1016/j.biopsych.2011.10.007
- PMID
- 22088795
- PMCID
- PMC3264698
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: AG010415, AG028748, AG107265, AI052737, CA116778, CA064710, CA140933, DK082344
- Language
- English
- Date published
- 2012
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065772602771
Metrics
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