Journal article
"Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
Schizophrenia bulletin, Vol.24(2), pp.203-218
1998
DOI: 10.1093/oxfordjournals.schbul.a033321
PMID: 9613621
Abstract
Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been replaced by models that postulate a disruption in parallel distributed or dynamic circuits. Based on empirical data derived from both magnetic resonance and positron emission tomography, we have developed a model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum. A disruption in this circuitry produces "cognitive dysmetria," difficulty in prioritizing, processing, coordinating, and responding to information. This "poor mental coordination" is a fundamental cognitive deficit in schizophrenia and can account for its broad diversity of symptoms.
Details
- Title: Subtitle
- "Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
- Creators
- Nancy C AndreasenSergio ParadisoDaniel S O'Leary
- Resource Type
- Journal article
- Publication Details
- Schizophrenia bulletin, Vol.24(2), pp.203-218
- DOI
- 10.1093/oxfordjournals.schbul.a033321
- PMID
- 9613621
- NLM abbreviation
- Schizophr Bull
- ISSN
- 0586-7614
- eISSN
- 1745-1701
- Publisher
- National Institute of Mental Health
- Language
- English
- Date published
- 1998
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003988902771
Metrics
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