Journal article
Cognitive Impairment in Huntington Disease: Diagnosis and Treatment
Current neurology and neuroscience reports, Vol.11(5), pp.474-483
10/01/2011
DOI: 10.1007/s11910-011-0215-x
PMCID: PMC3628771
PMID: 21861097
Abstract
Cognition has been well characterized in the various stages of Huntington disease (HD) as well as in the prodrome before the motor diagnosis is given. Although the clinical diagnosis of HD relies on the manifestation of motor abnormalities, the associated impairments have been growing in prominence for several reasons. First, research to understand the most debilitating aspects of HD has suggested that cognitive and behavioral changes place the greatest burden on families, are most highly associated with functional decline, and can be predictive of institutionalization. Second, cognitive impairments are evident at least 15 years prior to the time at which motor diagnosis is given. Finally, cognitive decline is associated with biological markers such as brain atrophy, circulating levels of brain-derived neurotrophic factors, and insulin-like growth factor 1. Efforts are now underway to develop valid and reliable measures of cognition in the prodrome as well as in all stages of HD so that clinical trials can be conducted using cognitive outcomes.
Details
- Title: Subtitle
- Cognitive Impairment in Huntington Disease: Diagnosis and Treatment
- Creators
- Jane S. Paulsen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current neurology and neuroscience reports, Vol.11(5), pp.474-483
- DOI
- 10.1007/s11910-011-0215-x
- PMID
- 21861097
- PMCID
- PMC3628771
- NLM abbreviation
- Curr Neurol Neurosci Rep
- ISSN
- 1528-4042
- eISSN
- 1534-6293
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- R01 NS054893 / National Institute of Neurological Disorders & Stroke, Cognitive and Functional Brain Changes in Preclinical HD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Huntington's Study Group CHDI Foundation, Inc. R01NS054893 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Schlesinger Associates Huntington's Disease Society of America National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CHDI Foundation R01 NS040068-11 / National Institutes for Health, National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 10/01/2011
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383897502771
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