Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness

Rachel E Luehrs; Kerrie L Moreau; Gary L Pierce; Frederick Wamboldt; Mark Aloia; Howard D Weinberger; Barry Make; Russell P Bowler; James D Crapo; Kimberly Meschede; Elizabeth Kozora; David J Moser; Karin F Hoth

doi:10.1152/japplphysiol.00477.2020

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Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness

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Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness

Rachel E Luehrs, Kerrie L Moreau, Gary L Pierce, Frederick Wamboldt, Mark Aloia, Howard D Weinberger, Barry Make, Russell P Bowler, James D Crapo, Kimberly Meschede, …

Journal of applied physiology (1985), Vol.131(1), pp.131-141

07/2021

DOI: 10.1152/japplphysiol.00477.2020

PMID: 33982592

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https://www.ncbi.nlm.nih.gov/pmc/articles/8325616View

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Abstract

Background: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are both independently associated with increased cardiovascular disease (CVD) risk and impaired cognitive function. It is unknown if individuals with both COPD and OSA (i.e. overlap syndrome) have greater common carotid artery (CCA) stiffness, an independent predictor of CVD risk, and lower cognitive performance than either COPD or OSA alone. Elevated CCA stiffness is associated with cognitive impairment in former smokers with and without COPD in past studies. Methods: We compared CCA stiffness and cognitive performance between former smokers with overlap syndrome, COPD only, OSA only and former smoker controls using analysis of covariance (ANCOVA) tests to adjust for age, sex, body mass index (BMI), pack-years and post-bronchodilator FEV1/FVC. We also examined the association between carotid artery stiffness and cognitive performance among each group separately. Results: Individuals with overlap syndrome (n=12) had greater CCA β-stiffness index (p=0.015) and lower executive function-processing speed (p=0.019) than individuals with COPD alone (n=47), OSA alone (n=9) and former smoker controls (n=21), differences that remained significant after adjusting for age, BMI, sex, pack-years and FEV1/FVC. Higher CCA β-stiffness index was associated with lower executive function-processing speed in individuals with overlap syndrome (r=-0.58, p=0.047). Conclusion: These data suggest that CCA stiffness is greater and cognitive performance is lower among individuals with overlap syndrome compared with individuals with COPD or OSA alone and that CCA stiffening may be an underlying mechanism contributing to the lower cognitive performance observed in patients with overlap syndrome.

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Title: Subtitle: Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness
Creators: Rachel E Luehrs - Department of Health and Human Physiology, University of Iowa, Iowa City, IA, United States, Department of Kinesiology, North Central College, Naperville, IL USA
Kerrie L Moreau - Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Gary L Pierce - Department of Health and Human Physiology, University of Iowa, Iowa City, IA, United States, Department of Internal Medicine, University of Iowa, Iowa City, IA, United States
Frederick Wamboldt - Department of Medicine, National Jewish Health, United States, Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Mark Aloia - Department of Medicine, National Jewish Health, United States
Howard D Weinberger - Department of Medicine, National Jewish Health, United States, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Barry Make - Department of Medicine, National Jewish Health, United States, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Russell P Bowler - Department of Medicine, National Jewish Health, United States, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
James D Crapo - Department of Medicine, National Jewish Health, United States, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Kimberly Meschede - Department of Medicine, National Jewish Health, United States
Elizabeth Kozora - Department of Medicine, National Jewish Health, United States, Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
David J Moser - Department of Psychiatry, University of Iowa, Iowa City, IA, United States
Karin F Hoth - Department of Psychiatry, University of Iowa, Iowa City, IA, United States, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.131(1), pp.131-141
DOI: 10.1152/japplphysiol.00477.2020
PMID: 33982592
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Grant note: DOI: 10.13039/100006108, name: HHS | NIH | National Center for Advancing Translational Sciences, award: UL1 TR001082; DOI: 10.13039/100006108, name: HHS | NIH | National Center for Advancing Translational Sciences, award: UL1 TR001356; DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: K23 HL095658; DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: R01 HL089897
Language: English
Date published: 07/2021
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Medicine Administration; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984077379802771

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