Journal article
Cognitive and volumetric predictors of response to repetitive transcranial magnetic stimulation (rTMS) - A prospective follow-up study
Psychiatry research. Neuroimaging, Vol.202(1), pp.12-19
04/30/2012
DOI: 10.1016/j.pscychresns.2012.02.004
PMID: 22608156
Abstract
As the prevalence of treatment resistant depression (TRD) continues to rise, it remains a clinically important issue to identify neurobiological-, patient- and treatment-related factors that could potentially predict response to treatment. Medial temporal lobe (MTL) structures, in particular the hippocampus and amygdala have been implicated in inferior treatment response. The role of related structures such as the entorhinal cortex and the impact of MTL abnormalities on neurocognitive function, however, have not been systematically examined. The current study investigated MTL abnormalities and neurocognitive characteristics of eventual treatment responders and non-responders to a course of repetitive transcranial magnetic stimulation (rTMS) in order to identify potential predictors of treatment outcome. Prior to rTMS treatment all patients underwent magnetic resonance imaging (MRI) and neuropsychological assessment. MRI analysis was conducted using FreeSurfer 5.0. There was a 50% response rate following up to a 6-week course of daily rTMS treatments. Treatment response was defined as 50% reduction in Hamilton Depression Rating Scale and BDI-II scores from baseline. There was no difference in pre-treatment neurocognitive profiles and MTL volumes between eventual treatment responders and non-responders. Smaller pre-treatment left hippocampus volume showed a trend towards predicting eventual subjective improvement in depressive symptomatology. Although preliminary, our findings suggest that structural abnormalities may have some potential for predicting outcome to rTMS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Cognitive and volumetric predictors of response to repetitive transcranial magnetic stimulation (rTMS) - A prospective follow-up study
- Creators
- Christina P. Furtado - Monash UniversityKate E. Hoy - Monash UniversityJerome J. Maller - Monash UniversityGreg Savage - ARC Centre of Excellence in Cognition and its DisordersZafiris J. Daskalakis - Centre for Addiction and Mental HealthPaul B. Fitzgerald - Monash University
- Resource Type
- Journal article
- Publication Details
- Psychiatry research. Neuroimaging, Vol.202(1), pp.12-19
- DOI
- 10.1016/j.pscychresns.2012.02.004
- PMID
- 22608156
- NLM abbreviation
- Psychiatry Res Neuroimaging
- ISSN
- 0925-4927
- eISSN
- 1872-7506
- Publisher
- Elsevier
- Number of pages
- 8
- Language
- English
- Date published
- 04/30/2012
- Academic Unit
- Radiology
- Record Identifier
- 9984848427202771
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