Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status

Leigh J. Beglinger; Kevin Duff; Jessica Allison; Danielle Theriault; Justin J. F. O'Rourke; Anne Leserman; Jane S. Paulsen

doi:10.1080/13803390903313564

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Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status

Journal article

Peer reviewed

Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status

Leigh J. Beglinger, Kevin Duff, Jessica Allison, Danielle Theriault, Justin J. F. O'Rourke, Anne Leserman and Jane S. Paulsen

Journal of clinical and experimental neuropsychology, Vol.32(6), pp.573-578

07/2010

DOI: 10.1080/13803390903313564

PMCID: PMC3806302

PMID: 19882420

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https://www.ncbi.nlm.nih.gov/pmc/articles/3806302View

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Abstract

Huntington disease (HD) is a neurodegenerative disease associated with cognitive, motor, and psychiatric deterioration over time. Although there is currently no cure for HD, there has been a surge of clinical trials available to patients with HD over the past 5 years. However, cognitive measures have generally been lacking from these trials. A brief, repeatable neuropsychological battery is needed to assess cognitive endpoints. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) may be useful for assessing change in interventional studies or for clinical monitoring. A total of 38 patients with HD were assessed using the RBANS, other cognitive tests, and the standardized HD battery (Unified Huntington's Disease Rating Scale, UHDRS) at two clinic visits approximately 16 months apart. The RBANS Attention Index, as well as individual subtest scores on Coding, Digit Span, List Recognition, Figure Copy, and Figure Recall all declined significantly over this interval. Performance on the UHDRS cognitive tests (Symbol Digit Modalities; Stroop Color, and Stroop Word) also declined, as did functional capacity. Results suggest that cognitive changes were detected both on established cognitive tasks used in HD research and on the RBANS in patients with measurable functional decline. The RBANS provided additional information about other cognitive domains affected (e.g., memory) and may be a useful measure for tracking longitudinal change.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences & Neurology

Psychology

Psychology, Clinical

Science & Technology

Social Sciences

Details

Title: Subtitle: Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status
Creators: Leigh J. Beglinger - University of Iowa
Kevin Duff - University of Iowa
Jessica Allison - University of Iowa
Danielle Theriault - University of Iowa
Justin J. F. O'Rourke - Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Anne Leserman - University of Iowa
Jane S. Paulsen - University of Iowa
Resource Type: Journal article
Publication Details: Journal of clinical and experimental neuropsychology, Vol.32(6), pp.573-578
DOI: 10.1080/13803390903313564
PMID: 19882420
PMCID: PMC3806302
NLM abbreviation: J Clin Exp Neuropsychol
ISSN: 1380-3395
eISSN: 1744-411X
Publisher: Taylor & Francis
Number of pages: 6
Grant note: R01 NS040068 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS040068 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
Language: English
Date published: 07/2010
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984383920902771

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