Journal article
Cognitive deficits in Huntington's disease on the Repeatable Battery for the Assessment of Neuropsychological Status
Journal of clinical and experimental neuropsychology, Vol.32(3), pp.231-238
03/2010
DOI: 10.1080/13803390902926184
PMCID: PMC2854844
PMID: 19484645
Abstract
Huntington's disease (HD) is associated with a variety of cognitive deficits, as well as motor and psychiatric disturbances. As clinical trials for HD evolve, briefer screening instruments will be needed to determine cognitive effects of interventions. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) may fill this gap. A total of 75 participants diagnosed with HD were evaluated with the RBANS, as well as several other scales typically used in HD. RBANS performances for these participants fell significantly below expectations for the Total Scale score, all five Indexes, and 11 of the 12 individual subtests. Cognitive scores on the RBANS were also significantly related to other markers of HD, including motor abnormalities, functional abilities, and other cognitive scores. Although additional research is needed, the current study supports the clinical applicability of the RBANS in patients with HD.
Details
- Title: Subtitle
- Cognitive deficits in Huntington's disease on the Repeatable Battery for the Assessment of Neuropsychological Status
- Creators
- Kevin Duff - University of IowaLeigh J. Beglinger - University of IowaDanielle Theriault - University of IowaJessica Allison - University of IowaJane S. Paulsen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical and experimental neuropsychology, Vol.32(3), pp.231-238
- DOI
- 10.1080/13803390902926184
- PMID
- 19484645
- PMCID
- PMC2854844
- NLM abbreviation
- J Clin Exp Neuropsychol
- ISSN
- 1380-3395
- eISSN
- 1744-411X
- Publisher
- Taylor & Francis
- Number of pages
- 8
- Grant note
- R01 NS040068; R01 NS040068-08 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) UL1 RR024979 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01NS040068 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) UL1RR024979 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Language
- English
- Date published
- 03/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383313602771
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