Journal article
Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
Neuropsychologia, Vol.40(12), pp.2178-2184
2002
DOI: 10.1016/S0028-3932(02)00043-X
PMID: 12208013
Abstract
Cognitive deficits have been well-documented in children with non-syndromic clefts of the lip and/or palate. However, no study to date has formally assessed cognition in adults with oral clefts. This study was designed to evaluate neuropsychological functioning in adult males with non-syndromic clefts of the lip and/or palate (
n=50) compared to age and sex-matched controls.
Subjects with oral clefts were found to have significantly lower full scale IQ, performance IQ and verbal IQ scores compared to their matched controls. After controlling for IQ, patients showed specific deficits in verbal fluency.
Adult males with oral clefts manifest a specific pattern of cognitive deficits. As the development of the face is highly interdependent with the development of the brain, it is theorized that the etiology of these cognitive deficits is a primary problem with abnormal brain development.
Details
- Title: Subtitle
- Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
- Creators
- Peg Nopoulos - Psychiatry Research, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USAStephanie Berg - Psychiatry Research, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USADuane VanDemark - Department of Otolaryngology, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USALynn Richman - Department of Pediatrics, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USAJohn Canady - Department of Otolaryngology, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USANancy C Andreasen - Psychiatry Research, University of Iowa College of Medicine, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neuropsychologia, Vol.40(12), pp.2178-2184
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0028-3932(02)00043-X
- PMID
- 12208013
- ISSN
- 0028-3932
- eISSN
- 1873-3514
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology
- Record Identifier
- 9984003930502771
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