Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions

Christopher M Nguyen; Torricia H Yamada; Leigh J Beglinger; Joseph E Cavanaugh; Natalie L Denburg; Susan K Schultz

doi:10.1002/pon.3086

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Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions

Journal article

Peer reviewed

Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions

Christopher M Nguyen, Torricia H Yamada, Leigh J Beglinger, Joseph E Cavanaugh, Natalie L Denburg and Susan K Schultz

Psycho-oncology (Chichester, England), Vol.22(4), pp.862-868

04/2013

DOI: 10.1002/pon.3086

PMCID: PMC3475736

PMID: 22585465

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https://www.ncbi.nlm.nih.gov/pmc/articles/3475736View

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Abstract

The present study examined the long-term cognitive implications of cancer treatment among breast cancer survivors aged 65 years and older to better understand the long term implications of cancer treatment. Fifty-seven women survivors were compared with 30 healthy older female adult comparisons, matched in terms of age and education, with no history of cancer. Cancer survivors were also compared on the basis of treatment intervention, involving chemotherapy (n = 27) versus local therapy through surgery and radiation (n = 30). As a group, the breast cancer survivors scored lower on measures of general cognitive function, working memory, psychomotor speed, and executive function when compared with the normal comparisons. Among the cancer survivors, those who received local therapy scored lower than the other survivors and normal comparisons on measures of verbal learning, visual perception and construction, as well as visual attention and short-term retention. Our findings suggest that cognitive outcomes may involve greater age-related deficits among older cancer survivors compared with matched healthy subjects.

Psychomotor Performance

Verbal Learning

Humans

Attention

Treatment Outcome

Cognition

Radiotherapy - adverse effects

Case-Control Studies

Breast Neoplasms - therapy

Neuropsychological Tests

Disease-Free Survival

Analysis of Variance

Time Factors

Antineoplastic Agents - adverse effects

Breast Neoplasms - psychology

Aged, 80 and over

Mastectomy

Female

Aged

Survivors - psychology

Memory, Short-Term

Executive Function

Details

Title: Subtitle: Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions
Creators: Christopher M Nguyen - Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242-1053, USA
Torricia H Yamada
Leigh J Beglinger
Joseph E Cavanaugh
Natalie L Denburg
Susan K Schultz
Resource Type: Journal article
Publication Details: Psycho-oncology (Chichester, England), Vol.22(4), pp.862-868
DOI: 10.1002/pon.3086
PMID: 22585465
PMCID: PMC3475736
NLM abbreviation: Psychooncology
ISSN: 1057-9249
eISSN: 1099-1611
Publisher: England
Grant note: 5 U18HSO16094 / PHS HHS K01 AG022033 / NIA NIH HHS K01AG022033 / NIA NIH HHS R01 CA122934 / NCI NIH HHS U18 HS016094 / AHRQ HHS R01CA122934 / NCI NIH HHS
Language: English
Date published: 04/2013
Academic Unit: Statistics and Actuarial Science; Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9983985891102771

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