Journal article
Cognitive function and retinal and ischemic brain changes The Women's Health Initiative
Neurology, Vol.78(13), pp.942-949
03/01/2012
DOI: 10.1212/WNL.0b013e31824d9655
PMCID: PMC3310310
PMID: 22422889
Abstract
Objective: To examine the association between retinopathy and cognitive decline or brain lesions and volumes in older women.
Methods: This study included 511 women aged 65 and older who were simultaneously enrolled in the Women's Health Initiative Memory Study and the Sight Examination Study. In this analysis, we examined the link between retinopathy, assessed using fundus photography (2000- 2002), cognitive performance over time assessed by the modified Mini-Mental State Examination (3MSE) (1996-2007), and white matter hyperintensities and lacunar infarcts in the basal ganglia.
Results: Presence of retinopathy was associated with poorer 3MSE scores (mean difference = 1.01, SE: 0.43) (p = 0.019) over a 10-year follow-up period and greater ischemic volumes in the total brain (47% larger, p = 0.04) and the parietal lobe (68% larger, p = 0.01) but not with measures of regional brain atrophy.
Conclusions: The correspondence we found between retinopathy and cognitive impairment, along with larger ischemic lesion volumes, strengthens existing evidence that retinopathy as a marker of small vessel disease is a risk factor for cerebrovascular disease that may influence cognitive performance and related brain changes. Retinopathy may be useful as a clinical tool if it can be shown to be an early marker related to neurologic outcomes. Neurology (R) 2012;78:942-949
Details
- Title: Subtitle
- Cognitive function and retinal and ischemic brain changes The Women's Health Initiative
- Creators
- M. Haan - University of California, San FranciscoM. A. Espeland - Wake Forest UniversityB. E. Klein - Univ Wisconsin, Dept Ophthalmol, Madison, WI 53706 USAR. Casanova - Wake Forest UniversityS. A. Gaussoin - Wake Forest UniversityR. D. Jackson - The Ohio State UniversityA. E. Millen - University at Buffalo, State University of New YorkS. M. Resnick - CognIT (Norway)J. E. Rossouw - NHLBI, Womens Hlth Initiat Branch, Div Cardiovasc Sci, Bethesda, MD 20892 USAS. A. Shumaker - Wake Forest UniversityR. Wallace - Univ Iowa, Coll Med, Dept Epidemiol, Iowa City, IA USAK. Yaffe - Univ Calif San Francisco, Dept Psychiat & Neurol, San Francisco, CA 94143 USAWomen’s Health Initiative Memory Study and the Women’s Health Initiative Sight Exam
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.78(13), pp.942-949
- DOI
- 10.1212/WNL.0b013e31824d9655
- PMID
- 22422889
- PMCID
- PMC3310310
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- National Heart, Lung, and Blood Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01WH032113 / WOMEN'S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA US Department of Health and Human Services Intramural Research Program, NIA, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) ZIAAG000190 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Wyeth Pharmaceuticals, Inc; Wyeth
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363614502771
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