Journal article
Cognitive task-related oscillations in human internal globus pallidus and subthalamic nucleus
Behavioural brain research, Vol.424, p.113787
02/07/2022
DOI: 10.1016/j.bbr.2022.113787
PMID: 35143905
Abstract
Recently it has been acknowledged that the basal ganglia nuclei play a major role in cognitive control; however, the contribution by their network remains unclear. Previous studies have demonstrated the role of the subthalamic nucleus (STN) in cognitive processing and suggested that its connections to cortical and other associated regions regulate response inhibition during conflict conditions. By contrast, the role of the internal globus pallidus (GPi) as the output nucleus before the thalamic relay has not yet been investigated during cognitive processing. We recorded local field potentials (LFPs) from externalized deep brain stimulation (DBS) electrodes implanted bilaterally in the GPi (n=9 participants with dystonia) and STN (n=8 participants with Parkinson's disease (PD)) during a primed flanker task. Both dystonia (GPi group) and PD participants (STN group) responded faster to the congruent trials than the incongruent trials. Overall, the dystonic GPi group was significantly faster than the PD STN group. LFPs showed elevated cue-triggered theta (3-7Hz) power in GPi and STN groups in a similar way. Response-triggered LFP beta power (13-25Hz) was significantly increased in the GPi group compared to the STN group. Results demonstrate that GPi activity appears to be critical in the cognitive processing of action selection and response during the presence of conflict tasks similar to the STN group.
Details
- Title: Subtitle
- Cognitive task-related oscillations in human internal globus pallidus and subthalamic nucleus
- Creators
- Muhammad Samran Navid - Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland, New ZealandStefan Kammermeier - Department of Neurology, Ludwig Maximilian University, Munich, GermanyImran K Niazi - Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland, New ZealandVibhash D Sharma - Department of Neurology, University of Kansas Medical Center, Kansas, USAShawn M Vuong - Division of Neurosurgery, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USAKai Bötzel - Department of Neurology, Ludwig Maximilian University, Munich, GermanyJeremy D W Greenlee - Department of Neurosurgery, University of Iowa, Iowa City, USAArun Singh - Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA. Electronic address: arun.singh@usd.edu
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.424, p.113787
- DOI
- 10.1016/j.bbr.2022.113787
- PMID
- 35143905
- NLM abbreviation
- Behav Brain Res
- eISSN
- 1872-7549
- Language
- English
- Date published
- 02/07/2022
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984215031402771
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