Journal article
Cold Injury
Hand clinics, Vol.25(4), pp.481-496
11/01/2009
DOI: 10.1016/j.hcl.2009.06.004
PMID: 19801122
Abstract
The pathophysiology of true frostbite reveals that the direct injury produced during the initial freeze process has a minor contribution to the global tissue damage. However, rapid rewarming to reverse the tissue crystallization has essentially been the lone frostbite intervention for almost half a century. The major pathologic process is the progressive microvascular thrombosis following reperfusion of the ischemic limb, with the cold-damaged endothelial cells playing a central role in the outcome of these frozen tissues. Newer interventions offer the opportunity to combat this process, and this article offers a scientific approach to frostbite injuries of the upper extremities.
Details
- Title: Subtitle
- Cold Injury
- Creators
- Wm J. Mohr - Regions HospitalKamrun Jenabzadeh - University of MinnesotaDavid H. Ahrenholz - Regions Hospital
- Resource Type
- Journal article
- Publication Details
- Hand clinics, Vol.25(4), pp.481-496
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.hcl.2009.06.004
- PMID
- 19801122
- ISSN
- 0749-0712
- eISSN
- 1558-1969
- Number of pages
- 16
- Language
- English
- Date published
- 11/01/2009
- Academic Unit
- Surgery
- Record Identifier
- 9984701642202771
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