Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

Elizabeth C Oelsner; Akshaya Krishnaswamy; Pallavi P Balte; Norrina Bai Allen; Tauqeer Ali; Pramod Anugu; Howard Andrews; Komal Arora; Alyssa Asaro; R Graham Barr; Alain G Bertoni; Jessica Bon; Rebekah Boyle; Arunee A Chang; Grace Chen; Sean Coady; Shelley A Cole; Josef Coresh; Elaine Cornell; Adolfo Correa; David Couper; Mary Cushman; Ryan T Demmer; Mitchell S V Elkind; Aaron R Folsom; Amanda M Fretts; Kelley Pettee Gabriel; Linda Gallo; Jose Gutierrez; Mei Lan K Han; Joel M Henderson; Virginia J Howard; Carmen R Isasi; David R Jacobs Jr; Suzanne E Judd; Debora Kamin Mukaz; Alka M Kanaya; Namratha R Kandula; Robert Kaplan; Gregory L Kinney; Anna Kucharska-Newton; Joyce S Lee; Cora E Lewis; Deborah A Levine; Emily B Levitan; Bruce Levy; Barry Make; Kimberly Malloy; Jennifer J Manly; Carolina Mendoza-Puccini; Katie A Meyer; Yuan-I Min; Matthew Moll; Wendy C Moore; Dave Mauger; Victor E Ortega; Priya Palta; Monica M Parker; Wanda Phipatanakul; Wendy S Post; Lisa Postow; Bruce M Psaty; Elizabeth A Regan; Kimberly Ring; Véronique L Roger; Jerome I Rotter; Tatjana Rundek; Ralph L Sacco; Michael Schembri; David A Schwartz; Sudha Seshadri; James M Shikany; Mario Sims; Karen D Hinckley Stukovsky; Gregory A Talavera; Russell P Tracy; Jason G Umans; Ramachandran S Vasan; Karol Watson; Sally E Wenzel; Karen Winters; Prescott G Woodruff; Vanessa Xanthakis; Ying Zhang; Yiyi Zhang; Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Investigators

doi:10.1093/aje/kwac032

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Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

Journal article

Open access

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Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

Elizabeth C Oelsner, Akshaya Krishnaswamy, Pallavi P Balte, Norrina Bai Allen, Tauqeer Ali, Pramod Anugu, Howard Andrews, Komal Arora, Alyssa Asaro, R Graham Barr, …

American journal of epidemiology, Vol.191(7), pp.1153-1173

03/12/2022

DOI: 10.1093/aje/kwac032

PMCID: PMC8992336

PMID: 35279711

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Abstract

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established United States (US) prospective cohort studies. Starting as early as 1971, C4R cohorts have collected data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health. C4R links this pre-COVID phenotyping to information on SARS-CoV-2 infection and acute and post-acute COVID-related illness. C4R is largely population-based, has an age range of 18–108 years, and reflects the racial, ethnic, socioeconomic, and geographic diversity of the US. C4R ascertains SARS-CoV-2 infection and COVID-19 illness using standardized questionnaires, ascertainment of COVID-related hospitalizations and deaths, and a SARS-CoV-2 serosurvey via dried blood spots. Master protocols leverage existing robust retention rates for telephone and in-person examinations, and high-quality events surveillance. Extensive pre-pandemic data minimize referral, survival, and recall bias. Data are harmonized with research-quality phenotyping unmatched by clinical and survey-based studies; these will be pooled and shared widely to expedite collaboration and scientific findings. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including post-acute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term trajectories of health.

Epidemiology

AcademicSubjects

cohort study

COVID-19

MED00860

Study Design

Details

Title: Subtitle: Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design
Creators: Elizabeth C Oelsner
Akshaya Krishnaswamy
Pallavi P Balte
Norrina Bai Allen
Tauqeer Ali
Pramod Anugu
Howard Andrews
Komal Arora
Alyssa Asaro
R Graham Barr
Alain G Bertoni
Jessica Bon
Rebekah Boyle
Arunee A Chang
Grace Chen
Sean Coady
Shelley A Cole
Josef Coresh
Elaine Cornell
Adolfo Correa
David Couper
Mary Cushman
Ryan T Demmer
Mitchell S V Elkind
Aaron R Folsom
Amanda M Fretts
Kelley Pettee Gabriel
Linda Gallo
Jose Gutierrez
Mei Lan K Han
Joel M Henderson
Virginia J Howard
Carmen R Isasi
David R Jacobs Jr
Suzanne E Judd
Debora Kamin Mukaz
Alka M Kanaya
Namratha R Kandula
Robert Kaplan
Gregory L Kinney
Anna Kucharska-Newton
Joyce S Lee
Cora E Lewis
Deborah A Levine
Emily B Levitan
Bruce Levy
Barry Make
Kimberly Malloy
Jennifer J Manly
Carolina Mendoza-Puccini
Katie A Meyer
Yuan-I Min
Matthew Moll
Wendy C Moore
Dave Mauger
Victor E Ortega
Priya Palta
Monica M Parker
Wanda Phipatanakul
Wendy S Post
Lisa Postow
Bruce M Psaty
Elizabeth A Regan
Kimberly Ring
Véronique L Roger
Jerome I Rotter
Tatjana Rundek
Ralph L Sacco
Michael Schembri
David A Schwartz
Sudha Seshadri
James M Shikany
Mario Sims
Karen D Hinckley Stukovsky
Gregory A Talavera
Russell P Tracy
Jason G Umans
Ramachandran S Vasan
Karol Watson
Sally E Wenzel
Karen Winters
Prescott G Woodruff
Vanessa Xanthakis
Ying Zhang - University of Oklahoma Health Sciences Center
Yiyi Zhang
Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Investigators
Contributors: Eric A Hoffman (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.191(7), pp.1153-1173
Publisher: Oxford University Press
DOI: 10.1093/aje/kwac032
PMID: 35279711
PMCID: PMC8992336
ISSN: 0002-9262
eISSN: 1476-6256
Language: English
Date published: 03/12/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Internal Medicine
Record Identifier: 9984318691002771

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