Journal article
Collagen network strengthening following cyclic tensile loading
Interface focus, Vol.6(1), pp.20150088-20150088
02/06/2016
DOI: 10.1098/rsfs.2015.0088
PMCID: PMC4686249
PMID: 26855760
Abstract
The bulk mechanical properties of tissues are highly tuned to the physiological
loads they experience and reflect the hierarchical structure and mechanical
properties of their constituent parts. A thorough understanding of the processes
involved in tissue adaptation is required to develop multi-scale computational
models of tissue remodelling. While extracellular matrix (ECM) remodelling is
partly due to the changing cellular metabolic activity, there may also be
mechanically directed changes in ECM nano/microscale organization which lead to
mechanical tuning. The thermal and enzymatic stability of collagen, which is the
principal load-bearing biopolymer in vertebrates, have been shown to be enhanced
by force suggesting that collagen has an active role in ECM mechanical
properties. Here, we ask how changes in the mechanical properties of a
collagen-based material are reflected by alterations in the micro/nanoscale
collagen network following cyclic loading. Surprisingly, we observed
significantly higher tensile stiffness and ultimate tensile strength, roughly
analogous to the effect of work hardening, in the absence of network realignment
and alterations to the fibril area fraction. The data suggest that mechanical
loading induces stabilizing changes internal to the fibrils themselves or in the
fibril–fibril interactions. If such a cell-independent strengthening
effect is operational
in vivo
, then it would be an important
consideration in any multiscale computational approach to ECM growth and
remodelling.
Details
- Title: Subtitle
- Collagen network strengthening following cyclic tensile loading
- Creators
- Monica E Susilo - Northeastern UniversityJeffrey A Paten - Northeastern UniversityEdward A Sander - University of IowaThao D Nguyen - Johns HopkinsJeffrey W Ruberti - Northeastern University
- Resource Type
- Journal article
- Publication Details
- Interface focus, Vol.6(1), pp.20150088-20150088
- DOI
- 10.1098/rsfs.2015.0088
- PMID
- 26855760
- PMCID
- PMC4686249
- NLM abbreviation
- Interface Focus
- ISSN
- 2042-8898
- eISSN
- 2042-8901
- Publisher
- The Royal Society
- Grant note
- NIH/NEI (R01) EY0015500 / ;
- Alternative title
- Cyclic Loading of Collagen Network
- Language
- English
- Date published
- 02/06/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984064114302771
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