Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature

Andrew M Bellizzi; Stacey E Mills

doi:10.1309/J3YVV58V22AKXHWR

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Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature

Journal article

Open access

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Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature

Andrew M Bellizzi and Stacey E Mills

American journal of clinical pathology, Vol.130(3), pp.355-362

09/2008

DOI: 10.1309/J3YVV58V22AKXHWR

PMID: 18701407

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Abstract

Since the first report of "tyrosine crystals" in a parotid mixed tumor by Bullock in 1953, authors have described several types of crystalloids in association with mixed tumor and related neoplastic and nonneoplastic entities. The principal classes of these include tyrosine-rich crystalloids, collagenous crystalloids, and one class variously referred to as tyrosine-rich crystals, nontyrosine crystalloids, and amylase crystalloids. We report a myoepithelial carcinoma of minor salivary gland origin containing numerous collagenous crystalloids. To our knowledge, this represents the first report of collagenous crystalloids in a case of myoepithelial carcinoma. In addition, we searched our institution's files for cases of pure myoepithelial tumors. No crystalloids of any form were identified in 27 myoepitheliomas and 15 myoepithelial carcinomas. We review the literature on salivary-related crystalloids, and we propose the term oncocyte/cyst-associated crystalloids to encompass the aforementioned third class of crystalloid. Given distinct morphologic and histochemical properties and given relatively limited disease associations, we conclude that in the appropriate clinical context, the identification of these crystalloids can be diagnostically useful.

Immunohistochemistry

Collagen - metabolism

Collagen - ultrastructure

Humans

Crystallization

Salivary Gland Neoplasms - ultrastructure

Female

Aged

Salivary Gland Neoplasms - pathology

Details

Title: Subtitle: Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature
Creators: Andrew M Bellizzi - Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Stacey E Mills
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.130(3), pp.355-362
DOI: 10.1309/J3YVV58V22AKXHWR
PMID: 18701407
NLM abbreviation: Am J Clin Pathol
ISSN: 0002-9173
eISSN: 1943-7722
Publisher: England
Language: English
Date published: 09/2008
Academic Unit: Pathology
Record Identifier: 9984047718402771

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