Journal article
Collectins and cationic antimicrobial peptides of the respiratory epithelia
Veterinary pathology, Vol.43(5), pp.595-612
09/2006
DOI: 10.1354/vp.43-5-595
PMCID: PMC2786072
PMID: 16966437
Abstract
The respiratory epithelium is a primary site for the deposition of microorganisms that are acquired during inspiration. The innate immune system of the respiratory tract eliminates many of these potentially harmful agents preventing their colonization. Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by respiratory epithelia, which have integral roles in host defense and inflammation in the lung. Synthesis and secretion of these molecules are regulated by the developmental stage, hormones, as well as many growth and immunoregulatory factors. The purpose of this review is to discuss antimicrobial innate immune elements within the respiratory tract of healthy and pneumonic lung with emphasis on hydrophilic surfactant proteins and beta-defensins.
Details
- Title: Subtitle
- Collectins and cationic antimicrobial peptides of the respiratory epithelia
- Creators
- B Grubor - Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA. branka.grubor@bms.comD K MeyerholzM R Ackermann
- Resource Type
- Journal article
- Publication Details
- Veterinary pathology, Vol.43(5), pp.595-612
- DOI
- 10.1354/vp.43-5-595
- PMID
- 16966437
- PMCID
- PMC2786072
- NLM abbreviation
- Vet Pathol
- ISSN
- 0300-9858
- eISSN
- 1544-2217
- Grant note
- R01 AI062787 / NIAID NIH HHS 5R01 AI 062787-02 / NIAID NIH HHS R01 AI062787-04 / NIAID NIH HHS K08 AI055499 / NIAID NIH HHS R01 AI062787-03 / NIAID NIH HHS 5K08 AI 055499-03 / NIAID NIH HHS
- Language
- English
- Date published
- 09/2006
- Academic Unit
- Pathology
- Record Identifier
- 9984083852802771
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