Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production

David E Elliott; Ahmed Metwali; John Leung; Tommy Setiawan; Arthur M Blum; M Nedim Ince; Lindsey E Bazzone; Miguel J Stadecker; Joseph F Urban Jr; Joel V Weinstock

doi:10.4049/jimmunol.181.4.2414

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Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production

Journal article

Peer reviewed

Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production

David E Elliott, Ahmed Metwali, John Leung, Tommy Setiawan, Arthur M Blum, M Nedim Ince, Lindsey E Bazzone, Miguel J Stadecker, Joseph F Urban Jr and Joel V Weinstock

The Journal of immunology (1950), Vol.181(4), pp.2414-2419

08/15/2008

DOI: 10.4049/jimmunol.181.4.2414

PMCID: PMC4242718

PMID: 18684931

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Abstract

Helminth exposure appears to protect hosts from inappropriate inflammatory responses, such as those causing inflammatory bowel disease. A recently identified, strongly proinflammatory limb of the immune response is characterized by T cell IL-17 production. Many autoimmune type inflammatory diseases are associated with IL-17 release. Because helminths protect from these diseases, we examined IL-17 production in helminth-colonized mice. We colonized mice with Heligmosomoides polygyrus, an intestinal helminth, and analyzed IL-17 production by lamina propria mononuclear cells (LPMC) and mesenteric lymph node (MLN) cells. Colonization with H. polygyrus reduces IL-17A mRNA by MLN cells and inhibits IL-17 production by cultured LPMC and MLN cells. Helminth exposure augments IL-4 and IL-10 production. Blocking both IL-4 and IL-10, but not IL-10 alone, restores IL-17 production in vitro. Colonization of colitic IL-10-deficient mice with H. polygyrus suppresses LPMC IL-17 production and improves colitis. Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation.

Intestinal Mucosa - metabolism

Strongylida Infections - metabolism

Nematospiroides dubius - immunology

Strongylida Infections - parasitology

Intestinal Mucosa - immunology

Strongylida Infections - immunology

Colitis - immunology

Interleukin-4 - physiology

Mice, Inbred C57BL

Cells, Cultured

Immune Tolerance

Lymph Nodes - metabolism

Mesentery

Nematospiroides dubius - growth & development

Interleukin-17 - biosynthesis

Lymph Nodes - immunology

Colitis - parasitology

Mice, Knockout

Interleukin-17 - metabolism

Animals

Lymph Nodes - parasitology

Interleukin-17 - antagonists & inhibitors

Colitis - metabolism

Mice

Intestinal Mucosa - parasitology

Details

Title: Subtitle: Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
Creators: David E Elliott - Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA. david-elliott@uiowa.edu
Ahmed Metwali
John Leung
Tommy Setiawan
Arthur M Blum
M Nedim Ince
Lindsey E Bazzone
Miguel J Stadecker
Joseph F Urban Jr
Joel V Weinstock
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.181(4), pp.2414-2419
DOI: 10.4049/jimmunol.181.4.2414
PMID: 18684931
PMCID: PMC4242718
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: R01 DK038327 / NIDDK NIH HHS DK38327 / NIDDK NIH HHS DK034928 / NIDDK NIH HHS P30 DK034928 / NIDDK NIH HHS DK07663 / NIDDK NIH HHS DK25295 / NIDDK NIH HHS R01 AI049382 / NIAID NIH HHS R56 DK058755 / NIDDK NIH HHS AI018919 / NIAID NIH HHS R01 AI018919 / NIAID NIH HHS DK58755 / NIDDK NIH HHS R01 DK058755 / NIDDK NIH HHS AI49382 / NIAID NIH HHS T32 DK007663 / NIDDK NIH HHS
Language: English
Date published: 08/15/2008
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094619702771

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