Journal article
Colonoscopy use following mutation detection in Lynch syndrome: Exploring a role for cancer screening in adaptation
Clinical genetics, Vol.79(4), pp.321-328
04/2011
DOI: 10.1111/j.1399-0004.2010.01622.x
PMCID: PMC3407565
PMID: 21204803
Abstract
Lynch syndrome is the most common inherited form of colorectal cancer. Mutation carriers can reduce the morbidity and mortality associated with colorectal cancer through colonoscopy. Theoretical models suggest that such health related behaviors might also bring psychological benefits. This study assessed whether colonoscopy following mutation detection was associated with levels of depressive symptoms.
Data were obtained from a prospective family cohort study offering genetic services for Lynch syndrome. Participants completed questionnaires prior to the provision of services and 6-months post receipt of mutation results. One hundred thirty four (134) persons were identified to carry a mutation and completed both questionnaires. Main outcome measures were depressive symptoms 6-months post-receipt of test results.
Mutation carriers who did not complete a colonoscopy within the 6 months following receipt of results were 6 times (p<0.01; OR=6.06) more likely to report depressive symptoms at a level of clinical importance compared to those who did undergo colonoscopy.
Facilitating the expeditious use of colonoscopy following mutation detection may benefit newly identified mutation carriers by addressing the objective risks for cancer and moderating underlying emotional distress responses to genetic risk information. Further, depressive symptoms may interfere with behavioral compliance in some patients, suggesting referral to mental health specialists.
Details
- Title: Subtitle
- Colonoscopy use following mutation detection in Lynch syndrome: Exploring a role for cancer screening in adaptation
- Creators
- Donald W Hadley - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MarylandSato Ashida - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MarylandJean F Jenkins - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MarylandKathleen A Calzone - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MarylandIlan R Kirsch - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MarylandLaura M Koehly - Social Network Methods Section, Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Division of Social and Behavioral Sciences, School of Public Health, University of Memphis, Memphis, Tennessee Office of the Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
- Resource Type
- Journal article
- Publication Details
- Clinical genetics, Vol.79(4), pp.321-328
- DOI
- 10.1111/j.1399-0004.2010.01622.x
- PMID
- 21204803
- PMCID
- PMC3407565
- NLM abbreviation
- Clin Genet
- ISSN
- 0009-9163
- eISSN
- 1399-0004
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Injury Prevention Research Center; Public Policy Center (Archive); Community and Behavioral Health
- Record Identifier
- 9984214846102771
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