Journal article
Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development
Scientific reports, Vol.8(1), pp.2979-10
02/14/2018
DOI: 10.1038/s41598-018-21368-z
PMCID: PMC5813178
PMID: 29445242
Abstract
Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and ATF1 rs11169552 (P = 4.36 × 10
) and DUSP10 rs6687758 (P = 1.25 × 10
), and positive association found with CASC8 rs10505477 (P = 8.2 × 10
). Additional CRC marker haplotypes were also significantly associated with TA. Genotyping an independent dataset consisting of 52 cases with TA and 427 controls confirmed the association with CASC8. Atf1 and Dusp10 expression was detected in the mouse developing teeth from early bud stages to the formation of the complete tooth, suggesting a potential role for these genes and their encoded proteins in tooth development. While their individual contributions in tooth development remain to be elucidated, these genes may be considered candidates to be tested in additional populations.
Details
- Title: Subtitle
- Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development
- Creators
- Meredith A Williams - Center for Craniofacial Research, University of Texas Health Science Center School of Dentistry, Houston, 77054, USAClaudia Biguetti - Department of Biological Sciences, University of Sao Paulo Bauru Dental School, Bauru, 17012, BrazilMiguel Romero-Bustillos - Iowa Institute for Oral Health, College of Dentistry, University of Iowa, Iowa City, 52242, USAKanwal Maheshwari - Center for Craniofacial Research, University of Texas Health Science Center School of Dentistry, Houston, 77054, USANuriye Dinckan - Department of Medical Genetics, School of Medicine, Istanbul University, Istanbul, 34093, TurkeyFranco Cavalla - Department of Biological Sciences, University of Sao Paulo Bauru Dental School, Bauru, 17012, BrazilXiaoming Liu - Department of Epidemiology and Human Genetics, University of Texas Health Science Center School of Public Health, Houston, 77054, USARenato Silva - Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, 77054, USASercan Akyalcin - Department of Orthodontics, Tufts University, Boston, 02111, USAZ Oya Uyguner - Department of Medical Genetics, School of Medicine, Istanbul University, Istanbul, 34093, TurkeyAlexandre R Vieira - Departments of Oral Biology and Pediatric Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, 15229, USABrad A Amendt - Craniofacial Anomalies Research Center, Carver College of Medicine, University of Iowa, Iowa City, 52242, USAWalid D Fakhouri - Department of Diagnostic and Biomedical Sciences, Sciences University of Texas Health Science Center School of Dentistry, Houston, 77054, USAAriadne Letra - Department of Diagnostic and Biomedical Sciences, Sciences University of Texas Health Science Center School of Dentistry, Houston, 77054, USA. Ariadne.M.Letra@uth.tmc.edu
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.8(1), pp.2979-10
- DOI
- 10.1038/s41598-018-21368-z
- PMID
- 29445242
- PMCID
- PMC5813178
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- R90 DE024296 / NIDCR NIH HHS T90 DE023520 / NIDCR NIH HHS
- Language
- English
- Date published
- 02/14/2018
- Academic Unit
- Orthodontics; Anatomy and Cell Biology; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025316802771
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