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Colorectal Cancer and Inflammatory Bowel Disease
Journal article   Peer reviewed

Colorectal Cancer and Inflammatory Bowel Disease

Maysoon Gamaleldin, Taha Qazi and Tracy Hull
Clinics in colon and rectal surgery, Vol.38(3), pp.198-202
05/01/2025
DOI: 10.1055/s-0044-1787891
PMCID: PMC12020543
PMID: 40291999
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC12020543/pdf/10-1055-s-0044-1787891.pdfView
Open Access

Abstract

Colorectal cancer (CRC) in patients with ulcerative colitis (UC) and Crohn's disease accounts for similar to 5% of all cases of CRC. Although it only accounts for a fraction of CRC cases, inflammatory bowel disease (IBD)-related CRC is a serious consequence of chronic inflammation that needs attention. There is a better understanding today about the pathogenesis contributing to IBD-CRC and the role of genetics and gut microbiota. Guidelines recommend timely screening and surveillance of UC and Crohn's patients, and it is usually timed from the initial diagnosis. This helps with early detection of dysplasia and CRC in this subset of patients, thus allowing for earlier intervention. However, dysplasia is not always easy to discern and management of CRC in each patient may differ. A multidisciplinary approach should be adopted in managing CRC in IBD. Although the oncologic principles of managing sporadic CRC and IBD-CRC are the same, surgical resection should be tailored to each patient.
 Gastroenterology & Hepatology Life Sciences & Biomedicine Science & Technology Surgery

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