Journal article
Colorectal Cancer and Metabolism
Current colorectal cancer reports, Vol.14(6), pp.226-241
12/01/2018
DOI: 10.1007/s11888-018-0420-y
PMCID: PMC6690608
PMID: 31406492
Abstract
Purpose of ReviewMetabolic reprogramming is essential for the rapid proliferation of cancer cells and is thus recognized as a hallmark of cancer. In this review, we will discuss the etiologies and effects of metabolic reprogramming in colorectal cancer.Recent FindingsChanges in cellular metabolism may precede the acquisition of driver mutations ultimately leading to colonocyte transformation. Oncogenic mutations and loss of tumor suppressor genes further reprogram CRC cells to upregulate glycolysis, glutaminolysis, one-carbon metabolism, and fatty acid synthesis. These metabolic changes are not uniform throughout tumors, as subpopulations of tumor cells may rely on different pathways to adapt to nutrient availability in the local tumor microenvironment. Finally, metabolic cross-communication between stromal cells, immune cells, and the gut microbiota enable CRC growth, invasion, and metastasis.SummaryAltered cellular metabolism occurs in CRC at multiple levels, including in the cells that make up the bulk of CRC tumors, cancer stem cells, the tumor microenvironment, and host-microbiome interactions. This knowledge may inform the development of improved screening and therapeutics for CRC.
Details
- Title: Subtitle
- Colorectal Cancer and Metabolism
- Creators
- Rachel E. Brown - Vanderbilt UniversitySarah P. Short - Vanderbilt University Medical CenterChristopher S. Williams - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Current colorectal cancer reports, Vol.14(6), pp.226-241
- Publisher
- Springer Nature
- DOI
- 10.1007/s11888-018-0420-y
- PMID
- 31406492
- PMCID
- PMC6690608
- ISSN
- 1556-3790
- eISSN
- 1556-3804
- Number of pages
- 16
- Grant note
- T32GM007347 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30DK058404 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK099204; 1F30DK120149; T32GM007347; 5F32 DK108492; P30DK058404 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA I01BX001426 / Veterans Affairs; US Department of Veterans Affairs 1I01 BX001426 / Office of Medical Research, Department of Veterans Affairs (Merit Review Grants)
- Language
- English
- Date published
- 12/01/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984420941902771
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