Journal article
ComBat Harmonization of Myocardial Radiomic Features Sensitive to Cardiac MRI Acquisition Parameters
Radiology. Cardiothoracic imaging, Vol.5(4)
07/27/2023
DOI: 10.1148/ryct.220312
PMCID: PMC10483256
PMID: 37693205
Abstract
Purpose: To investigate the effect of ComBat harmonization methods on the robustness of cardiac MRI-derived radiomic features to variations in imaging parameters.
Materials and methods: This Health Insurance Portability and Accountability Act-compliant retrospective study used a publicly available data set of 11 healthy controls (mean age, 33 years ± 16 [SD]; six men) and five patients (mean age, 52 years ± 16; four men). A single midventricular short-axis section was acquired with 3-T MRI using cine balanced steady-state free precision, T1-weighted, T2-weighted, T1 mapping, and T2 mapping imaging sequences. Each sequence was acquired using baseline parameters and after variations in flip angle, spatial resolution, section thickness, and parallel imaging. Image registration was performed for all sequences at a per-individual level. Manual myocardial contouring was performed, and 1652 radiomic features per sequence were extracted using baseline and variations in imaging parameters. Radiomic feature stability to change in imaging parameters was assessed using Cohen d sensitivity. The stability of radiomic features was assessed both without and after ComBat harmonization of radiomic features. Three ComBat methods were studied: parametric, nonparametric, and Gaussian mixture model (GMM).
Results: For all sequences combined, 51.4% of features were robust to changes in imaging parameters when no ComBat method was applied. ComBat harmonization substantially increased the number of stable features to 95.1% (95% CI: 94.9, 95.3) when parametric ComBat was used and 90.9% (95% CI: 90.6, 91.2) when nonparametric ComBat was used. GMM combat resulted in only 52.6% stable features.
Conclusion: ComBat harmonization improved the stability of radiomic features to changes in imaging parameters across all cardiac MRI sequences.Keywords: Cardiac MRI, Radiomics, ComBat, Harmonization Supplemental material is available for this article.
Details
- Title: Subtitle
- ComBat Harmonization of Myocardial Radiomic Features Sensitive to Cardiac MRI Acquisition Parameters
- Creators
- Sarv Priya - University of IowaDurjoy D. Dhruba - University of IowaEldon Sorensen - University of IowaPritish Y. Aher - University of IowaSabarish Narayanasamy - University of IowaPrashant Nagpal - University of IowaMathews Jacob - University of IowaKnute D. Carter - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Radiology. Cardiothoracic imaging, Vol.5(4)
- Publisher
- Radiological Society of North America
- DOI
- 10.1148/ryct.220312
- PMID
- 37693205
- PMCID
- PMC10483256
- ISSN
- 2638-6135
- eISSN
- 2638-6135
- Language
- English
- Date published
- 07/27/2023
- Academic Unit
- Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Biostatistics; Radiation Oncology
- Record Identifier
- 9984461960002771
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