Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial

Andrei Iagaru; Erik Mittra; Camila Mosci; David W Dick; Mike Sathekge; Vineet Prakash; Victor Iyer; Paula Lapa; Jorge Isidoro; Joao M de Lima; Sanjiv Sam Gambhir

doi:10.2967/jnumed.112.108803

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Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial

Journal article

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Peer reviewed

Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial

Andrei Iagaru, Erik Mittra, Camila Mosci, David W Dick, Mike Sathekge, Vineet Prakash, Victor Iyer, Paula Lapa, Jorge Isidoro, Joao M de Lima, …

The Journal of nuclear medicine (1978), Vol.54(2), pp.176-183

02/2013

DOI: 10.2967/jnumed.112.108803

PMID: 23243299

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Abstract

(18)F-FDG PET/CT is used in a variety of cancers, but because of variable rates of glucose metabolism, not all cancers are reliably identified. (18)F(-) PET/CT allows for the acquisition of highly sensitive and specific images of the skeleton. We prospectively evaluated combined (18)F(-)/(18)F-FDG as a single PET/CT examination for evaluation of cancer patients and compared it with separate (18)F(-) PET/CT and (18)F-FDG PET/CT scans. One hundred fifteen participants with cancer were prospectively enrolled in an international multicenter trial evaluating (18)F(-) PET/CT, (18)F-FDG PET/CT, and combined (18)F(-)/(18)F-FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. (18)F(-)/(18)F-FDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of (18)F-FDG PET/CT. In 19 participants, skeletal disease was more extensive on (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT than on (18)F-FDG PET/CT. In another 29 participants, (18)F(-) PET/CT and (18)F(-)/(18)F-FDG PET/CT showed osseous metastases where (18)F-FDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. This trial demonstrated that combined (18)F(-)/(18)F-FDG PET/CT shows promising results when compared with separate (18)F(-) PET/CT and (18)F-FDG PET/CT for evaluation of cancer patients. This result opens the possibility for improved patient care and reduction in health-care costs, as will be further evaluated in future trials.

Prospective Studies

Humans

Middle Aged

Tomography, X-Ray Computed - methods

Male

Neoplasms - diagnosis

Neoplasm Metastasis

Bone and Bones - metabolism

Aged, 80 and over

Adult

Female

Medical Oncology - methods

Reproducibility of Results

Bone Neoplasms - diagnosis

Bone Neoplasms - diagnostic imaging

International Cooperation

Image Processing, Computer-Assisted - methods

Positron-Emission Tomography - methods

Neoplasms - diagnostic imaging

Pilot Projects

Nuclear Medicine - methods

Glucose - metabolism

Fluorodeoxyglucose F18

Aged

Fluorine Radioisotopes

Details

Title: Subtitle: Combined 18F-fluoride and 18F-FDG PET/CT scanning for evaluation of malignancy: results of an international multicenter trial
Creators: Andrei Iagaru - Division of Nuclear Medicine, Stanford University Medical Center, Stanford, California 94305, USA. aiagaru@stanford.edu
Erik Mittra
Camila Mosci
David W Dick
Mike Sathekge
Vineet Prakash
Victor Iyer
Paula Lapa
Jorge Isidoro
Joao M de Lima
Sanjiv Sam Gambhir
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.54(2), pp.176-183
Publisher: United States
DOI: 10.2967/jnumed.112.108803
PMID: 23243299
ISSN: 0161-5505
eISSN: 1535-5667
Grant note: CA114747 / NCI NIH HHS
Language: English
Date published: 02/2013
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051533102771

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