Combined Dynamic Contrast-Enhanced Liver MRI and MRA Using Interleaved Variable Density Sampling

Mahdi Salmani Rahimi; Frank R. Korosec; Kang Wang; James H. Holmes; Utaroh Motosugi; Peter Bannas; Scott B. Reeder

doi:10.1002/mrm.25195

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Combined Dynamic Contrast-Enhanced Liver MRI and MRA Using Interleaved Variable Density Sampling

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Combined Dynamic Contrast-Enhanced Liver MRI and MRA Using Interleaved Variable Density Sampling

Mahdi Salmani Rahimi, Frank R. Korosec, Kang Wang, James H. Holmes, Utaroh Motosugi, Peter Bannas and Scott B. Reeder

Magnetic resonance in medicine, Vol.73(3), pp.973-983

03/01/2015

DOI: 10.1002/mrm.25195

PMCID: PMC4167159

PMID: 24639130

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Abstract

PurposeTo develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. MethodsAn interleaved variable density (IVD) undersampling pattern was implemented in combination with a real-time-triggered, time-resolved, dual-echo 3D spoiled gradient echo sequence. Parallel imaging autocalibration lines were acquired only once during the first time frame. Imaging was performed in 10 subjects with focal nodular hyperplasia (FNH) and compared with their clinical MRI. The angiographic phase of the proposed method was compared with a dedicated MR angiogram acquired during a second injection of contrast. ResultsA total of 21 FNH, three cavernous hemangiomas, and 109 arterial segments were visualized in 10 subjects. The temporally resolved images depicted the characteristic arterial enhancement pattern of the lesions with a 4-s update rate. Images were graded as having significantly higher quality compared with the clinical MRI. Angiograms produced from the IVD method provided noninferior diagnostic assessment compared with the dedicated MR angiogram. ConclusionUsing an undersampled IVD imaging method, we have demonstrated the feasibility of obtaining high spatial and temporal resolution dynamic contrast-enhanced imaging and simultaneous MRA of the liver. Magn Reson Med 73:973-983, 2015. (c) 2014 Wiley Periodicals, Inc.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Combined Dynamic Contrast-Enhanced Liver MRI and MRA Using Interleaved Variable Density Sampling
Creators: Mahdi Salmani Rahimi - University of Wisconsin–Madison
Frank R. Korosec - University of Wisconsin–Madison
Kang Wang - Global MR Applications & Workflow GE Healthcare Madison Wisconsin USA
James H. Holmes - Global MR Applications & Workflow GE Healthcare Madison Wisconsin USA
Utaroh Motosugi - University of Wisconsin–Madison
Peter Bannas - University of Wisconsin–Madison
Scott B. Reeder - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine, Vol.73(3), pp.973-983
DOI: 10.1002/mrm.25195
PMID: 24639130
PMCID: PMC4167159
NLM abbreviation: Magn Reson Med
ISSN: 0740-3194
eISSN: 1522-2594
Publisher: Wiley
Number of pages: 11
Grant note: R&D Committee of University of Wisconsin Department of Radiology RC1EB010384 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RC1EB010384 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
Language: English
Date published: 03/01/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984295023402771

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