Journal article
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
American journal of human genetics, Vol.77(4), pp.582-595
10/2005
DOI: 10.1086/491603
PMCID: PMC1275607
PMID: 16175504
Abstract
Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficulty and potential pitfalls of the implementation. We conducted a combined analysis using the original genotype data from 11 BP genomewide linkage scans comprising 5,179 individuals from 1,067 families. Heterogeneity among studies was minimized in our analyses by using uniform methods of analysis and a common, standardized marker map and was assessed using novel methods developed for meta-analysis of genome scans. To date, this collaboration is the largest and most comprehensive analysis of linkage samples involving a psychiatric disorder. We demonstrate that combining original genome-scan data is a powerful approach for the elucidation of linkage regions underlying complex disease. Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches.
Details
- Title: Subtitle
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
- Creators
- Matthew B McQueen - Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA. mmcqueen@hsph.harvard.eduB DevlinStephen V FaraoneVishwajit L NimgaonkarPamela SklarJordan W SmollerRami Abou JamraMargot AlbusSilviu-Alin BacanuMiron BaronThomas B BarrettWade BerrettiniDeborah BlackerWilliam ByerleySven CichonWillam CoryellNick CraddockMark J DalyJ Raymond DepauloHoward J EdenbergTatiana ForoudMichael GillT Conrad GilliamMarian HamshereIan JonesLisa JonesSuh-Hang JuoJohn R KelsoeDavid LambertChristoph LangeBernard LererJianjun LiuWolfgang MaierJames D MackinnonMelvin G McInnisFrancis J McMahonDennis L MurphyMarkus M NothenJohn I NurnbergerCarlos N PatoMichele T PatoJames B PotashPeter ProppingAnn E PulverJohn P RiceMarcella RietschelWilliam ScheftnerJohannes SchumacherRicardo SeguradoKristel Van SteenWeiting XiePeter P ZandiNan M Laird
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.77(4), pp.582-595
- Publisher
- United States
- DOI
- 10.1086/491603
- PMID
- 16175504
- PMCID
- PMC1275607
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Grant note
- R01 MH059535 / NIMH NIH HHS MH63420 / NIMH NIH HHS R01 MH59553 / NIMH NIH HHS R01 MH59602 / NIMH NIH HHS R01 MH60068 / NIMH NIH HHS R01 MH063445 / NIMH NIH HHS N01HG65403 / NHGRI NIH HHS R01 MH59545 / NIMH NIH HHS R01 MH059548 / NIMH NIH HHS U01 MH46280 / NIMH NIH HHS 1Z01MH002810-01 / NIMH NIH HHS R01-MH063445 / NIMH NIH HHS R01 MH59533 / NIMH NIH HHS R01 HD060726 / NICHD NIH HHS MH0667288 / NIMH NIH HHS R01 MH059567 / NIMH NIH HHS U01 MH46274 / NIMH NIH HHS R01 MH059556 / NIMH NIH HHS Z01 MH002810 / Intramural NIH HHS U01 MH46282 / NIMH NIH HHS R01 MH059545 / NIMH NIH HHS R01 MH59567 / NIMH NIH HHS R01 MH059533 / NIMH NIH HHS R01 MH059534 / NIMH NIH HHS T32 MH017119 / NIMH NIH HHS R01 MH059553 / NIMH NIH HHS R01 MH59535 / NIMH NIH HHS T32-MH017119 / NIMH NIH HHS R01 MH060068 / NIMH NIH HHS R01 MH063420 / NIMH NIH HHS
- Language
- English
- Date published
- 10/2005
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003931002771
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