Journal article
Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration
Journal of bone and mineral research, Vol.20(5), pp.848-857
2005
DOI: 10.1359/JBMR.041226
PMID: 15824858
Abstract
Bone formation is a coordinated process involving various biological factors. We have developed a scaffold system capable of sustained and localized presentation of osteogenic (BMP-4) and angiogenic (VEGF) growth factors and human bone marrow stromal cells to promote bone formation at an ectopic site. Combined delivery of these factors significantly enhanced bone formation compared with other conditions.
Details
- Title: Subtitle
- Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration
- Creators
- Yen-Chen HUANG - Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United StatesDarnell KAIGLER - Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, United StatesKevin G RICE - College of Pharmacy, University of Iowa, Iowa City, Iowa, United StatesPaul H KREBSBACH - Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United StatesDavid J MOONEY - Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States
- Resource Type
- Journal article
- Publication Details
- Journal of bone and mineral research, Vol.20(5), pp.848-857
- DOI
- 10.1359/JBMR.041226
- PMID
- 15824858
- NLM abbreviation
- J Bone Miner Res
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- Publisher
- American Society for Bone and Mineral Research; Duham, NC
- Language
- English
- Date published
- 2005
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Nephrology; Medicinal and Natural Products Chemistry; Internal Medicine
- Record Identifier
- 9984065314902771
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