Journal article
Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the International Childhood Cardiovascular Cohort Consortium
Circulation (New York, N.Y.), Vol.128(3), pp.217-224
07/16/2013
DOI: 10.1161/CIRCULATIONAHA.113.001614
PMCID: PMC3875837
PMID: 23780579
Abstract
Elevated blood pressure (BP) levels in childhood have been associated with subsequent atherosclerosis. However, it is uncertain whether this risk is attenuated in individuals who acquire normal BP by adulthood. The present study examined the effect of child and adult BP levels on carotid artery intima-media thickness (IMT) in adulthood.
The cohort consisted of 4210 participants from 4 prospective studies (mean follow-up, 23 years). Childhood elevated BP was defined according to the tables from the National High Blood Pressure Education Program. In adulthood, BP was classified as elevated for individuals with systolic BP ≥120 mm Hg, diastolic BP ≥80 mm Hg or with self-reported use of antihypertensive medications. Carotid artery IMT was measured in the left common carotid artery. High IMT was defined as an IMT ≥90th percentile according to age-, sex-, race-, and cohort-specific levels. Individuals with persistently elevated BP and individuals with normal childhood BP, but elevated adult BP had increased risk of high carotid artery IMT (relative risk [95% confidence interval]) 1.82[1.47-2.38] and 1.57[1.22-2.02], respectively) in comparison with individuals with normal child and adult BP. In contrast, individuals with elevated BP as children but not as adults did not have significantly increased risk (1.24[0.92-1.67]). In addition, these individuals had a lower risk of increased carotid artery IMT (0.66[0.50-0.88]) in compared with those with persistently elevated BP. The results were consistent when controlling for age, sex, and adiposity and when different BP definitions were applied.
Individuals with persistently elevated BP from childhood to adulthood had increased risk of carotid atherosclerosis. This risk was reduced if elevated BP during childhood resolved by adulthood.
Details
- Title: Subtitle
- Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the International Childhood Cardiovascular Cohort Consortium
- Creators
- Jonna Juhola - Turku University HospitalCostan G Magnussen - University of TasmaniaGerald S Berenson - Tulane UniversityAlison Venn - University of TasmaniaTrudy L Burns - University of IowaMatthew A Sabin - Royal Children's HospitalSathanur R Srinivasan - Tulane UniversityStephen R Daniels - University of Colorado HospitalPatricia H Davis - University of IowaWei Chen - Tulane UniversityMika Kähönen - University of TampereLeena Taittonen - Vaasa Central HospitalElaine Urbina - Cincinnati Children's Hospital Medical CenterJorma S A Viikari - Turku University HospitalTerence Dwyer - Murdoch Children's Research InstituteOlli T Raitakari - Turku University HospitalMarkus Juonala - Turku University Hospital
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.128(3), pp.217-224
- DOI
- 10.1161/CIRCULATIONAHA.113.001614
- PMID
- 23780579
- PMCID
- PMC3875837
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Grant note
- P30 ES005605 / NIEHS NIH HHS R01 ES021724 / NIEHS NIH HHS M01 RR000059 / NCRR NIH HHS RR-00059 / NCRR NIH HHS AG-16592 / NIA NIH HHS R01 HL054730 / NHLBI NIH HHS ES-021724 / NIEHS NIH HHS UL1 TR000077 / NCATS NIH HHS HL-54730 / NHLBI NIH HHS HL-14230 / NHLBI NIH HHS R01 AG016592 / NIA NIH HHS
- Language
- English
- Date published
- 07/16/2013
- Academic Unit
- Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363662702771
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