Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Laura L Jelliffe-Pawlowski; Kelli K Ryckman; Bruce Bedell; Hugh M O'Brodovich; Jeffrey B Gould; Dierdre J Lyell; Kristi S Borowski; Gary M Shaw; Jeffrey C Murray; David K Stevenson

doi:10.1016/j.ajog.2014.02.019

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Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Journal article

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Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth

Laura L Jelliffe-Pawlowski, Kelli K Ryckman, Bruce Bedell, Hugh M O'Brodovich, Jeffrey B Gould, Dierdre J Lyell, Kristi S Borowski, Gary M Shaw, Jeffrey C Murray and David K Stevenson

American journal of obstetrics and gynecology, Vol.211(2), pp.141.e1-141.e9

08/2014

DOI: 10.1016/j.ajog.2014.02.019

PMCID: PMC4117727

PMID: 24831886

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Abstract

The objective of the study was to determine whether pregnancies resulting in early preterm birth (PTB) (<30 weeks) were more likely than term pregnancies to have elevated midtrimester serum tumor necrosis factor alpha (TNF-α) levels combined with lipid patterns suggestive of hyperlipidemia. In 2 nested case-control samples drawn from California and Iowa cohorts, we examined the frequency of elevated midpregnancy serum TNF-α levels (in the fourth quartile [4Q]) and lipid patterns suggestive of hyperlipidemia (eg, total cholesterol, low-density-lipoproteins, or triglycerides in the 4Q, high-density lipoproteins in the first quartile) (considered independently and by co-occurrence) in pregnancies resulting in early PTB compared with those resulting in term birth (n = 108 in California and n = 734 in Iowa). Odds ratios (ORs) and 95% confidence intervals (CIs) estimated in logistic regression models were used for comparisons. Early preterm pregnancies were 2-4 times more likely than term pregnancies to have a TNF-α level in the 4Q co-occurring with indicators of hyperlipidemia (37.5% vs 13.9% in the California sample (adjusted OR, 4.0; 95% CI, 1.1–16.3) and 26.3% vs 14.9% in the Iowa sample (adjusted OR, 2.7; 95% CI, 1.1–6.3). No differences between early preterm and term pregnancies were observed when TNF-α or target lipid abnormalities occurred in isolation. Observed differences were not explicable to any maternal or infant characteristics. Pregnancies resulting in early PTB were more likely than term pregnancies to have elevated midpregnancy TNF-α levels in combination with lipid patterns suggestive of hyperlipidemia.

hyperlipidemia

early preterm birth

tumor necrosis factor alpha

term pregnancy

Details

Title: Subtitle: Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth
Creators: Laura L Jelliffe-Pawlowski - Genetic Disease Screening Program, California Department of Public Health, Richmond, and the Division of Preventive Medicine and Public Health, Department of Epidemiology and Biostatistics, University of California, San Francisco, School of Medicine, San Francisco, CA
Kelli K Ryckman - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
Bruce Bedell - Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA
Hugh M O'Brodovich - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
Jeffrey B Gould - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
Dierdre J Lyell - Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA
Kristi S Borowski - California Perinatal Quality Care Collaborative, Palo Alto, CA
Gary M Shaw - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
Jeffrey C Murray - Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA
David K Stevenson - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.211(2), pp.141.e1-141.e9
DOI: 10.1016/j.ajog.2014.02.019
PMID: 24831886
PMCID: PMC4117727
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: 6-FY11-261; FY10-180 / March of Dimes RC2 HL101748; R01 HD-57192; R01 HD-52953 / National Institutes of Health/National Heart, Lung, and Blood Institute OPP52256; RSDP 5K12 HD-00849-23 / March of Dimes Prematurity Center at Stanford University School of Medicine, Bill and Melinda Gates Millennium
Language: English
Date published: 08/2014
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
Record Identifier: 9983996198402771

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