Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis

Waleed Al-Herz; Luigi D Notarangelo; Ali Sadek; Rebecca Buckley; USIDNET Consortium

doi:10.1016/j.clim.2015.07.013

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Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis

Journal article

Open access

Peer reviewed

Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis

Waleed Al-Herz, Luigi D Notarangelo, Ali Sadek, Rebecca Buckley and USIDNET Consortium

Clinical immunology (Orlando, Fla.), Vol.161(2), pp.170-173

12/2015

DOI: 10.1016/j.clim.2015.07.013

PMCID: PMC4869855

PMID: 26248333

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https://www.ncbi.nlm.nih.gov/pmc/articles/4869855View

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Abstract

To compare different variables among (S)CID patients diagnosed in the USA and Kuwait. Review of patients registered in The US Immune Deficiency Network registry or Kuwait National PID Registry between 2004 and 2014. Totals of 98 and 69 (S)CID patients were registered during the study period in the USIDNET registry and the KNPIDR, respectively. The average annual incidence rate for the period 2004-2014 of (S)CID in children in Kuwait was 13.01/100,000 children, with an estimated occurrence of 1/7500 live births. There were differences between the two countries in the following variables: age at onset and diagnosis, family history of (S)CID, parental consanguinity, and outcome. More than 14% of (S)CID patients from USIDNET registry were diagnosed through newborn screening. Patients' characteristics and molecular causes of S(CID) are different between USA and Kuwait. NBS for SCID should be started in countries where the incidence of (S)CID is high.

Registries

Age of Onset

Child

Humans

Immunologic Deficiency Syndromes - diagnosis

Immunologic Deficiency Syndromes - epidemiology

Infant, Newborn

Kuwait - epidemiology

Neonatal Screening - methods

Pathology, Molecular - methods

United States - epidemiology

Details

Title: Subtitle: Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis
Creators: Waleed Al-Herz - Al-Sabah Hospital
Luigi D Notarangelo - Harvard University
Ali Sadek - National Health Information Center
Rebecca Buckley - Duke University
USIDNET Consortium
Contributors: Zuhair K Ballas (Contributor) - University of Iowa, Immunology
Resource Type: Journal article
Publication Details: Clinical immunology (Orlando, Fla.), Vol.161(2), pp.170-173
DOI: 10.1016/j.clim.2015.07.013
PMID: 26248333
PMCID: PMC4869855
NLM abbreviation: Clin Immunol
ISSN: 1521-6616
eISSN: 1521-7035
Grant note: R18 AI048693 / NIAID NIH HHS U24 AI086037 / NIAID NIH HHS P01 AI061093 / NIAID NIH HHS
Language: English
Date published: 12/2015
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984359856902771

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