Journal article
Combined lesion-deficit and fMRI approaches in single-case studies: unique contributions to cognitive neuroscience
Current opinion in behavioral sciences, Vol.40, pp.58-63
08/2021
DOI: 10.1016/j.cobeha.2021.01.004
PMID: 33709012
Abstract
•The number of published neuroscience papers on single-case studies is declining.•Combining lesion-deficit case studies and functional imaging yields valuable insights.•These insights go beyond those obtained by lesion-deficit or functional imaging alone.
Although lesion-deficit case studies are foundational in cognitive neuroscience, published papers presenting single lesion cases are declining. In this review, we argue that there is a valuable place for single-case lesion-deficit research, especially when combined with functional neuroimaging methods, such as functional magnetic resonance imaging (fMRI). To support this, we present a summary of notable findings from single-case combined lesion-deficit and fMRI studies published in recent years (2017–2020). These studies show the unique value that this combined approach brings to the understanding of complex functions, brain-level connectivity, and plasticity and recovery. We encourage researchers to consider combining lesion-deficit and functional imaging methods in the analysis of single cases, as this approach affords unique opportunities to address challenging unanswered questions about brain–behavior relationships.
Details
- Title: Subtitle
- Combined lesion-deficit and fMRI approaches in single-case studies: unique contributions to cognitive neuroscience
- Creators
- Carolina Deifelt Streese - Department of Neurology, Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242, United StatesDaniel Tranel - Department of Neurology, Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242, United States
- Resource Type
- Journal article
- Publication Details
- Current opinion in behavioral sciences, Vol.40, pp.58-63
- DOI
- 10.1016/j.cobeha.2021.01.004
- PMID
- 33709012
- NLM abbreviation
- Curr Opin Behav Sci
- ISSN
- 2352-1546
- eISSN
- 2352-1554
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000025, name: National Institute of Mental Health
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984070659002771
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