Journal article
Combining brain perturbation and neuroimaging in non-human primates
NeuroImage (Orlando, Fla.), Vol.235, pp.118017-118017
07/15/2021
DOI: 10.1016/j.neuroimage.2021.118017
PMID: 33794355
Abstract
•Combined brain perturbation and neuroimaging can reveal causal brain mechanisms.•Overview of perturbation methods used with non-human primate neuroimaging.•Methodological considerations of the different techniques are discussed.•Translational potential and future directions are laid out and critically assessed.
Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.
Details
- Title: Subtitle
- Combining brain perturbation and neuroimaging in non-human primates
- Creators
- P. Christiaan Klink - Department of Vision & Cognition, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, the NetherlandsJean-François Aubry - Physics for Medicine Paris, Inserm U1273, CNRS UMR 8063, ESPCI Paris, PSL University, Paris, FranceVincent P Ferrera - Department of Neuroscience & Department of Psychiatry, Columbia University Medical Center, New York, NY, USAAndrew S Fox - Department of Psychology & California National Primate Research Center, University of California, Davis, CA, USASean Froudist-Walsh - Center for Neural Science, New York University, New York, NY, USABéchir Jarraya - NeuroSpin, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Institut National de la Santé et de la Recherche Médicale (INSERM), Cognitive Neuroimaging Unit, Université Paris-Saclay, FranceElisa E Konofagou - Ultrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USARichard J Krauzlis - Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, USAAdam Messinger - Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USAAnna S Mitchell - Department of Experimental Psychology, Oxford University, Oxford, United KingdomMichael Ortiz-Rios - Newcastle University Medical School, Newcastle upon Tyne NE1 7RU, United KingdomHiroyuki Oya - Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USAAngela C Roberts - Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, United KingdomAnna Wang Roe - Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, ChinaMatthew F.S Rushworth - Department of Experimental Psychology, Oxford University, Oxford, United KingdomJérôme Sallet - Department of Experimental Psychology, Oxford University, Oxford, United KingdomMichael Christoph Schmid - Newcastle University Medical School, Newcastle upon Tyne NE1 7RU, United KingdomCharles E Schroeder - Nathan Kline Institute, Orangeburg, NY, USAJordy Tasserie - NeuroSpin, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Institut National de la Santé et de la Recherche Médicale (INSERM), Cognitive Neuroimaging Unit, Université Paris-Saclay, FranceDoris Y Tsao - Division of Biology and Biological Engineering, Tianqiao and Chrissy Chen Institute for Neuroscience; Howard Hughes Medical Institute; Computation and Neural Systems, Caltech, Pasadena, CA, USALynn Uhrig - NeuroSpin, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Institut National de la Santé et de la Recherche Médicale (INSERM), Cognitive Neuroimaging Unit, Université Paris-Saclay, FranceWim Vanduffel - Laboratory for Neuro- and Psychophysiology, Neurosciences Department, KU Leuven Medical School, Leuven, BelgiumMelanie Wilke - German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, GermanyIgor Kagan - German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, GermanyChristopher I Petkov - Newcastle University Medical School, Newcastle upon Tyne NE1 7RU, United Kingdom
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.235, pp.118017-118017
- DOI
- 10.1016/j.neuroimage.2021.118017
- PMID
- 33794355
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000011, name: Howard Hughes Medical Institute; DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100000053, name: National Eye Institute; DOI: 10.13039/100007862, name: California National Primate Research Center; DOI: 10.13039/100010663, name: European Research Council; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China; DOI: 10.13039/501100003130, name: Research Foundation Flanders; DOI: 10.13039/501100004731, name: Zhejiang Province Natural Science Foundation
- Language
- English
- Date published
- 07/15/2021
- Academic Unit
- Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070350202771
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