Journal article
Commissural nucleus of the solitary tract lesions reduce food intake and body weight gain in rats
Brain research, Vol.740(1), pp.102-108
1996
DOI: 10.1016/S0006-8993(96)00850-5
PMID: 8973803
Abstract
This study investigated the effects of an electrolytic lesion of the commissural subnucleus of the nucleus of the solitary tract (commNTS) on body weight, daily food and water intake, and plasma glucose and insulin in rats. In the first 6 days following brain surgery, commNTS lesioned rats reduced daily food intake by 80% compared to rats with sham lesions. After this period rats with lesions of commNTS started recovering food intake, but intake remained significantly reduced until the 12th day after surgery. A reduction in body weight was observed 4 days after surgery and reached a maximum on the 12th day. After this, a partial recovery of body weight was observed, but weight remained significantly reduced compared to weights of rats with sham lesions through the conclusion of the study. Food intake and body weight gain in other rats with partial lesions of the commNTS or with lesions outside the commNTS did not differ from rats with sham lesions with regard to those variables. Daily water intake and plasma glucose and insulin were not changed by the commNTS lesions. These results suggest that commNTS is involved with mechanisms that control food intake and body weight in rats.
Details
- Title: Subtitle
- Commissural nucleus of the solitary tract lesions reduce food intake and body weight gain in rats
- Creators
- Jose Vanderlei Menani - Departments of Psychology, Pharmacology and Neurology, and the Cardiovascular Center, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USAEduardo Colombari - Departments of Psychology, Pharmacology and Neurology, and the Cardiovascular Center, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USAWilliam T Talman - Departments of Psychology, Pharmacology and Neurology, and the Cardiovascular Center, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USAAlan Kim Johnson - Departments of Psychology, Pharmacology and Neurology, and the Cardiovascular Center, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.740(1), pp.102-108
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(96)00850-5
- PMID
- 8973803
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1996
- Academic Unit
- Neurology; Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213424202771
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