Journal article
Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease
Journal of Alzheimer's disease, Vol.46(2), pp.491-495
2015
DOI: 10.3233/JAD-150110
PMCID: PMC6312181
PMID: 26402410
Abstract
The phospholipase D3 (PLD3) gene has shown association with Alzheimer's disease (AD). However, the role of PLD3 common variants in amyloid-β (Aβ) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) Aβ(1- 42) levels and florbetapir retention on florbetapir 18F amyloid positron emission tomography (AV45-PET) in a large population. We found that one SNP (rs11667768) was significantly associated with CSF Aβ(1- 42) levels in the normal cognition group. We did not observe an association of any SNP with florbetapir retention. Our study predicted the potential role of PLD3 variants in Aβ pathology.
Details
- Title: Subtitle
- Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease
- Creators
- Chong Wang - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, ChinaLan Tan - Department of Radiology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, ChinaHui-Fu Wang - Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, ChinaWan-Jiang Yu - Department of Radiology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, ChinaYing Liu - Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, ChinaTeng Jiang - Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, ChinaMeng-Shan Tan - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, ChinaXiao-Ke Hao - Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaDao-Qiang Zhang - Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaJin-Tai Yu - Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USAAlzheimer’s Disease Neuroimaging Initiative
- Contributors
- Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Journal of Alzheimer's disease, Vol.46(2), pp.491-495
- DOI
- 10.3233/JAD-150110
- PMID
- 26402410
- PMCID
- PMC6312181
- NLM abbreviation
- J Alzheimers Dis
- ISSN
- 1387-2877
- eISSN
- 1875-8908
- Publisher
- Netherlands
- Grant note
- U01 AG024904 / NIA NIH HHS P30 AG013846 / NIA NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051564702771
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