Common medial frontal mechanisms of adaptive control in humans and rodents

Nandakumar S Narayanan; James F Cavanagh; Michael J Frank; Mark Laubach

doi:10.1038/nn.3549

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Common medial frontal mechanisms of adaptive control in humans and rodents

Journal article

Peer reviewed

Common medial frontal mechanisms of adaptive control in humans and rodents

Nandakumar S Narayanan, James F Cavanagh, Michael J Frank and Mark Laubach

Nature neuroscience, Vol.16(12), pp.1888-1895

12/2013

DOI: 10.1038/nn.3549

PMCID: PMC3840072

PMID: 24141310

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https://figshare.com/articles/preprint/Common_medial_frontal_mechanisms_of_adaptive_control_in_humans_and_rodents/23888853View

Open Access

Abstract

In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cingulate regions of the MFC in rats. These oscillations were phase locked between the MFC and motor areas in both rats and humans. In rats, single neurons that encoded prior behavioral outcomes were phase coherent with low-frequency field oscillations, particularly after errors. Inactivating the medial frontal regions in rats led to impaired behavioral adjustments after errors, eliminated the differential expression of low-frequency oscillations after errors and increased low-frequency spike-field coupling within the motor cortex. Our results describe a new mechanism for behavioral adaptation through low-frequency oscillations and elucidate how medial frontal networks synchronize brain activity to guide performance.

Brain Waves - physiology

Acoustic Stimulation

Humans

Rats, Long-Evans

Adaptation, Physiological - physiology

Rats

Male

Electroencephalography

Reaction Time - physiology

Frontal Lobe - physiology

Young Adult

Animals

Brain Mapping

Conditioning, Operant

Female

Time Perception - physiology

Details

Title: Subtitle: Common medial frontal mechanisms of adaptive control in humans and rodents
Creators: Nandakumar S Narayanan - Department of Neurology, Carver College of Medicine, The University of Iowa
James F Cavanagh - Cognitive, Linguistic & Psychological Sciences, Brown Institute for Brain Science, Psychiatry and Human Behavior, Brown University
Michael J Frank - Department of Psychiatry, and Brown Institute for Brain Science, Brown University
Mark Laubach - The John B. Pierce Laboratory and Department of Neurobiology, Yale University School of Medicine
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.16(12), pp.1888-1895
DOI: 10.1038/nn.3549
PMID: 24141310
PMCID: PMC3840072
NLM abbreviation: Nat Neurosci
ISSN: 1097-6256
eISSN: 1546-1726
Publisher: United States
Grant note: K08 NS078100 / NINDS NIH HHS P01 AG030004 / NIA NIH HHS R01 MH080066 / NIMH NIH HHS P01-AG030004-01A1 / NIA NIH HHS MH080066-01 / NIMH NIH HHS
Language: English
Date published: 12/2013
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020606902771

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